Serine/threonine protein kinase NLK is an
enzyme that in humans is encoded by the NLKgene.[5][6][7] Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophilaortholog of the mammalian NLK gene.[8] This enzyme is a member of the
Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual
phosphorylation motifs of typical MAPKs, and is not phosphorylated by any known
MAP2 kinases). Its activation mechanism and downstream targets are still not well characterized.[9]
^Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W (Jul 2000). "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts". Gene. 251 (1): 63–71.
doi:
10.1016/S0378-1119(00)00188-8.
PMID10863097.
Volorio S, Simon G, Repetto M, et al. (1999). "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein". DNA Seq. 9 (5–6): 307–15.
doi:
10.3109/10425179809008469.
PMID10524757.
Kortenjann M, Wehrle C, Nehls MC, Boehm T (2002). "Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes". Gene. 278 (1–2): 161–5.
doi:
10.1016/S0378-1119(01)00710-7.
PMID11707333.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204.
PMID12107411.
Serine/threonine protein kinase NLK is an
enzyme that in humans is encoded by the NLKgene.[5][6][7] Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophilaortholog of the mammalian NLK gene.[8] This enzyme is a member of the
Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual
phosphorylation motifs of typical MAPKs, and is not phosphorylated by any known
MAP2 kinases). Its activation mechanism and downstream targets are still not well characterized.[9]
^Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W (Jul 2000). "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts". Gene. 251 (1): 63–71.
doi:
10.1016/S0378-1119(00)00188-8.
PMID10863097.
Volorio S, Simon G, Repetto M, et al. (1999). "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein". DNA Seq. 9 (5–6): 307–15.
doi:
10.3109/10425179809008469.
PMID10524757.
Kortenjann M, Wehrle C, Nehls MC, Boehm T (2002). "Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes". Gene. 278 (1–2): 161–5.
doi:
10.1016/S0378-1119(01)00710-7.
PMID11707333.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204.
PMID12107411.