The
imidazole portion of imiloxan is prepared by the reaction of an
imidate with the diethyl acetal of
aminoacetaldehyde. N-Alkylation of the imidazole with
ethyl iodide gives imiloxan.
^Cobos-Puc LE, Villalón CM, Sánchez-López A, Lozano-Cuenca J, Pertz HH, Görnemann T, Centurión D (January 2007). "Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats". European Journal of Pharmacology. 554 (2–3): 205–11.
doi:
10.1016/j.ejphar.2006.09.068.
PMID17109851.
The
imidazole portion of imiloxan is prepared by the reaction of an
imidate with the diethyl acetal of
aminoacetaldehyde. N-Alkylation of the imidazole with
ethyl iodide gives imiloxan.
^Cobos-Puc LE, Villalón CM, Sánchez-López A, Lozano-Cuenca J, Pertz HH, Görnemann T, Centurión D (January 2007). "Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats". European Journal of Pharmacology. 554 (2–3): 205–11.
doi:
10.1016/j.ejphar.2006.09.068.
PMID17109851.