Clinical data | |
---|---|
Trade names | Intracef, Velocef |
AHFS/ Drugs.com | International Drug Names |
MedlinePlus | a601206 |
Routes of administration | Oral, IM, IV |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | Well absorbed |
Protein binding | <10% |
Metabolism | Nil |
Elimination half-life | 0.9 hours |
Excretion | Renal, unchanged |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.049.199 |
Chemical and physical data | |
Formula | C16H19N3O4S |
Molar mass | 349.41 g·mol−1 |
3D model ( JSmol) | |
Melting point | 140 to 142 °C (284 to 288 °F) (dec.) |
| |
| |
(verify) |
Cefradine ( INN) or cephradine ( BAN) is a first generation cephalosporin antibiotic. [1]
Cefradine is distributed in the form of capsules containing 250 mg or 500 mg, as a syrup containing 250 mg/5 ml, or in vials for injection containing 500 mg or 1 g.[ citation needed]
It is not approved by the FDA for use in the United States.[ citation needed]
Birch reduction of D-α- phenylglycine led to diene (2). This was N-protected using tert-butoxycarbonylazide and activated for amide formation via the mixed anhydride method using isobutylchloroformate to give 3. Mixed anhydride 3 reacted readily with 7-aminodesacetoxycephalosporanic acid to give, after deblocking, cephradine (5).
The antibiotic is produced under many brand names across the world. [5]
Clinical data | |
---|---|
Trade names | Intracef, Velocef |
AHFS/ Drugs.com | International Drug Names |
MedlinePlus | a601206 |
Routes of administration | Oral, IM, IV |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | Well absorbed |
Protein binding | <10% |
Metabolism | Nil |
Elimination half-life | 0.9 hours |
Excretion | Renal, unchanged |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.049.199 |
Chemical and physical data | |
Formula | C16H19N3O4S |
Molar mass | 349.41 g·mol−1 |
3D model ( JSmol) | |
Melting point | 140 to 142 °C (284 to 288 °F) (dec.) |
| |
| |
(verify) |
Cefradine ( INN) or cephradine ( BAN) is a first generation cephalosporin antibiotic. [1]
Cefradine is distributed in the form of capsules containing 250 mg or 500 mg, as a syrup containing 250 mg/5 ml, or in vials for injection containing 500 mg or 1 g.[ citation needed]
It is not approved by the FDA for use in the United States.[ citation needed]
Birch reduction of D-α- phenylglycine led to diene (2). This was N-protected using tert-butoxycarbonylazide and activated for amide formation via the mixed anhydride method using isobutylchloroformate to give 3. Mixed anhydride 3 reacted readily with 7-aminodesacetoxycephalosporanic acid to give, after deblocking, cephradine (5).
The antibiotic is produced under many brand names across the world. [5]