| Aztreonam | |
|---|---|
| Drug class | |
 | |
| Class identifiers | |
| Use | Bacterial infection |
| ATC code | J01DF |
| External links | |
| MeSH | D008997 |
| Legal status | |
| In Wikidata | |
Monobactams are bacterially-produced monocyclic β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams. [1]
Monobactams are narrow-spectrum antibiotics [2] effective only against (strictly or facultatively [3]) aerobic Gram-negative bacilli, [4] [5] [3] exhibiting a high level of resistance to beta-lactamases of these organisms. [3] Due to their narrow spectrum, monobactams can be used to treat infections by susceptible bacteria without disrupting the patient's microbiota. [2] Monobactams are nevertheless seldom used. [2]
Aztreonam is the principal [4] and sole commercially available member of monobactams. [6] Other monobactams include tigemonam, [7] nocardicin A, and tabtoxin.[ citation needed]
Pharmacology
Monobactams exert their antibacterial effects by binding to penicillin-binding proteins (PBPs), thereby inhibiting bacterial wall synthesis. [5] Monobactams exhibit poor affinity for PBPs of Gram-positive bactera as well as of strictly anaerobic bacteria, resulting in a lack of significant antimicrobial activity against these kinds of organisms. [3] Monobactams are synergetic with aminoglycosides, and piperacillin. [5]
Bacterial resistance to monobactams have been observed, and is mediated by bacterial beta-lactamases. [5]
Adverse effects
Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.[ citation needed]
Monobactam antibiotics exhibit no IgE cross-reactivity reactions with penicillin but have shown some cross reactivity with cephalosporins, most notably ceftazidime, which contains an identical side chain as aztreonam. [8] Monobactams can trigger seizures in patients with history of seizures, although the risk is lower than with penicillins.[ citation needed]
Research
Siderophore-conjugated monobactams show promise for the treatment of multi drug-resistant pathogens. [9]
References
- ^ Klaus R. Lindner; Daniel P. Bonner; William H. Koster (2000). "Monobactams". Kirk-Othmer Encyclopedia of Chemical Technology. Wiley-VCH. doi: 10.1002/0471238961.1315141512091404.a01. ISBN 0471238961.
- ^ a b c Murray, Patrick R.; Rosenthal, Ken S.; Pfaller, Michael A. (2021). Medical microbiology (9th ed.). Elsevier. p. 172. ISBN 978-0-323-67450-8.
- ^ a b c d Sherris Medical Microbiology - 7th Edition. p. 437.
- ^ a b Ritter, James; Flower, Rod; Henderson, Graeme; Loke, Yoon Kong; MacEwan, David; Rang, H. P. (2020). Rang & Dale's Pharmacology (9th ed.). Elsevier. p. 665. ISBN 978-0-7020-7448-6.
- ^ a b c d "Dictionnaire médical de l'Académie de Médecine". www.academie-medecine.fr. Retrieved 2024-01-13.
- ^ "Monobactams - Infectious Diseases". MSD Manual Professional Edition. Retrieved 2024-01-13.
- ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. doi: 10.1128/aac.32.3.346. PMC 172173. PMID 3259122.
-
^ Alldredge, Brian K.; Corelli, Robin L.; Ernst, Michael E. (February 2012). Applied therapeutics : the clinical use of drugs. Alldredge, Brian K.,, Revision of: Koda-Kimble, Mary Anne., Revision of: Young, Lloyd Y. (Tenth ed.). Philadelphia.
ISBN
9781609137137.
OCLC
759179443.
{{ cite book}}: CS1 maint: location missing publisher ( link) -
^ Gumienna-Kontecka, Elzbieta; Carver, Peggy L. (2019). "Chapter 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases". In Sigel, Astrid; Freisinger, Eva; Sigel, Roland K. O.; Carver, Peggy L. (Guest editor) (eds.). Essential Metals in Medicine:Therapeutic Use and Toxicity of Metal Ions in the Clinic. Vol. 19. Berlin: de Gruyter GmbH. pp. 181–202.
doi:
10.1515/9783110527872-013.
ISBN
978-3-11-052691-2.
PMID
30855108.
S2CID
73727689.
{{ cite book}}:|editor4-first=has generic name ( help);|journal=ignored ( help)
External links
- Monobactams at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it. |
| Aztreonam | |
|---|---|
| Drug class | |
|
| |
| Class identifiers | |
| Use | Bacterial infection |
| ATC code | J01DF |
| External links | |
| MeSH | D008997 |
| Legal status | |
| In Wikidata | |
Monobactams are bacterially-produced monocyclic β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams. [1]
Monobactams are narrow-spectrum antibiotics [2] effective only against (strictly or facultatively [3]) aerobic Gram-negative bacilli, [4] [5] [3] exhibiting a high level of resistance to beta-lactamases of these organisms. [3] Due to their narrow spectrum, monobactams can be used to treat infections by susceptible bacteria without disrupting the patient's microbiota. [2] Monobactams are nevertheless seldom used. [2]
Aztreonam is the principal [4] and sole commercially available member of monobactams. [6] Other monobactams include tigemonam, [7] nocardicin A, and tabtoxin.[ citation needed]
Pharmacology
Monobactams exert their antibacterial effects by binding to penicillin-binding proteins (PBPs), thereby inhibiting bacterial wall synthesis. [5] Monobactams exhibit poor affinity for PBPs of Gram-positive bactera as well as of strictly anaerobic bacteria, resulting in a lack of significant antimicrobial activity against these kinds of organisms. [3] Monobactams are synergetic with aminoglycosides, and piperacillin. [5]
Bacterial resistance to monobactams have been observed, and is mediated by bacterial beta-lactamases. [5]
Adverse effects
Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.[ citation needed]
Monobactam antibiotics exhibit no IgE cross-reactivity reactions with penicillin but have shown some cross reactivity with cephalosporins, most notably ceftazidime, which contains an identical side chain as aztreonam. [8] Monobactams can trigger seizures in patients with history of seizures, although the risk is lower than with penicillins.[ citation needed]
Research
Siderophore-conjugated monobactams show promise for the treatment of multi drug-resistant pathogens. [9]
References
- ^ Klaus R. Lindner; Daniel P. Bonner; William H. Koster (2000). "Monobactams". Kirk-Othmer Encyclopedia of Chemical Technology. Wiley-VCH. doi: 10.1002/0471238961.1315141512091404.a01. ISBN 0471238961.
- ^ a b c Murray, Patrick R.; Rosenthal, Ken S.; Pfaller, Michael A. (2021). Medical microbiology (9th ed.). Elsevier. p. 172. ISBN 978-0-323-67450-8.
- ^ a b c d Sherris Medical Microbiology - 7th Edition. p. 437.
- ^ a b Ritter, James; Flower, Rod; Henderson, Graeme; Loke, Yoon Kong; MacEwan, David; Rang, H. P. (2020). Rang & Dale's Pharmacology (9th ed.). Elsevier. p. 665. ISBN 978-0-7020-7448-6.
- ^ a b c d "Dictionnaire médical de l'Académie de Médecine". www.academie-medecine.fr. Retrieved 2024-01-13.
- ^ "Monobactams - Infectious Diseases". MSD Manual Professional Edition. Retrieved 2024-01-13.
- ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. doi: 10.1128/aac.32.3.346. PMC 172173. PMID 3259122.
-
^ Alldredge, Brian K.; Corelli, Robin L.; Ernst, Michael E. (February 2012). Applied therapeutics : the clinical use of drugs. Alldredge, Brian K.,, Revision of: Koda-Kimble, Mary Anne., Revision of: Young, Lloyd Y. (Tenth ed.). Philadelphia.
ISBN
9781609137137.
OCLC
759179443.
{{ cite book}}: CS1 maint: location missing publisher ( link) -
^ Gumienna-Kontecka, Elzbieta; Carver, Peggy L. (2019). "Chapter 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases". In Sigel, Astrid; Freisinger, Eva; Sigel, Roland K. O.; Carver, Peggy L. (Guest editor) (eds.). Essential Metals in Medicine:Therapeutic Use and Toxicity of Metal Ions in the Clinic. Vol. 19. Berlin: de Gruyter GmbH. pp. 181–202.
doi:
10.1515/9783110527872-013.
ISBN
978-3-11-052691-2.
PMID
30855108.
S2CID
73727689.
{{ cite book}}:|editor4-first=has generic name ( help);|journal=ignored ( help)
External links
- Monobactams at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
|
| This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it. |