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CAS Number | |
PubChem CID | |
Chemical and physical data | |
Formula | C24H36O2 |
Molar mass | 356.550 g·mol−1 |
3D model ( JSmol) | |
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JWH-138 (THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesized by Roger Adams and studied heavily by John W. Huffman, with a Ki of 8.5nM at the CB1 cannabinoid receptor. [1] THC-Octyl and its hydrogenated analog HHC-Octyl was synthesized and studied by Roger Adams as early as 1942. [2]
The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be slightly less active than Δ3-THC itself. [3] The alternate isomer Δ9-THC-C8 has also been synthesised, [4] and both the Δ8 and Δ9 isomers are included within the definition of an "intoxicating cannabinoid" in Colorado under the name tetrahydrocannabioctyl, [5] but it is unclear if it has been identified as a natural product. Tetrahydrocannabioctyl is sometimes referred to as THC-Octyl or THC-O, which may cause confusion with THC-O-acetate which is commonly known as THC-O on packaging for grey market vaping liquids sold for use in humans.
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
Chemical and physical data | |
Formula | C24H36O2 |
Molar mass | 356.550 g·mol−1 |
3D model ( JSmol) | |
| |
|
JWH-138 (THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesized by Roger Adams and studied heavily by John W. Huffman, with a Ki of 8.5nM at the CB1 cannabinoid receptor. [1] THC-Octyl and its hydrogenated analog HHC-Octyl was synthesized and studied by Roger Adams as early as 1942. [2]
The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be slightly less active than Δ3-THC itself. [3] The alternate isomer Δ9-THC-C8 has also been synthesised, [4] and both the Δ8 and Δ9 isomers are included within the definition of an "intoxicating cannabinoid" in Colorado under the name tetrahydrocannabioctyl, [5] but it is unclear if it has been identified as a natural product. Tetrahydrocannabioctyl is sometimes referred to as THC-Octyl or THC-O, which may cause confusion with THC-O-acetate which is commonly known as THC-O on packaging for grey market vaping liquids sold for use in humans.