4-Iodopropofol is a drug derived from the commonly used
sedativeanaesthetic agent,
propofol. 4-Iodopropofol has similar effects to propofol on isolated receptors, acting primarily as a
GABAA positive modulator and
sodium channel blocker,[1][2][3][4] but when given to animals it has only
anxiolytic and
anticonvulsant effects, lacking the strong sedative-hypnotic profile of propofol.[5]
References
^Trapani G, Latrofa A, Franco M, Altomare C, Sanna E, Usala M, et al. (May 1998). "Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors". Journal of Medicinal Chemistry. 41 (11): 1846–54.
doi:
10.1021/jm970681h.
PMID9599235.
4-Iodopropofol is a drug derived from the commonly used
sedativeanaesthetic agent,
propofol. 4-Iodopropofol has similar effects to propofol on isolated receptors, acting primarily as a
GABAA positive modulator and
sodium channel blocker,[1][2][3][4] but when given to animals it has only
anxiolytic and
anticonvulsant effects, lacking the strong sedative-hypnotic profile of propofol.[5]
References
^Trapani G, Latrofa A, Franco M, Altomare C, Sanna E, Usala M, et al. (May 1998). "Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors". Journal of Medicinal Chemistry. 41 (11): 1846–54.
doi:
10.1021/jm970681h.
PMID9599235.