![]() Tebipenem pivoxil | |
Clinical data | |
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Trade names | Orapenem |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
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Identifiers | |
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CAS Number | |
UNII | |
KEGG | |
PDB ligand | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C22H31N3O6S2 |
Molar mass | 497.63 g·mol−1 |
3D model ( JSmol) | |
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Tebipenem (brand name Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. [1] [2] Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. [3] It has performed well in clinical trials for ear infection and looks likely to be further developed in future. [4] It is only marketed in Japan. [5] Tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available. [6]
![]() Tebipenem pivoxil | |
Clinical data | |
---|---|
Trade names | Orapenem |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
UNII | |
KEGG | |
PDB ligand | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C22H31N3O6S2 |
Molar mass | 497.63 g·mol−1 |
3D model ( JSmol) | |
|
Tebipenem (brand name Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. [1] [2] Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. [3] It has performed well in clinical trials for ear infection and looks likely to be further developed in future. [4] It is only marketed in Japan. [5] Tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available. [6]