From Wikipedia, the free encyclopedia
Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of
cell surface receptors activated by
endogenous
steroids that mediate rapid,
non-genomic
signaling via modulation of
intracellular signaling cascades.
[1]
[2]
[3]
[4] mSRs are another means besides classical
nuclear
steroid hormone receptors (SHRs) for steroids to mediate their
biological effects.
[1]
[2]
[3]
[4] SHRs can produce slow genomic responses or rapid, non-genomic responses in the case of mSRs.
[5]
List of membrane steroid receptors
Known groups of mSRs, by ligand, include:
[a]
- Membrane sex steroid receptors
-
Membrane estrogen receptors (mERs) –
GPER,
ER-X,
ERx,
Gq-mER;
Nav1.2;
[6] palmitoylated nuclear receptors
[6]
-
Membrane progesterone receptors (mPRs) –
PAQRs (
mPRα,
mPRβ,
mPRγ,
mPRδ,
mPRϵ);
PGRMC1,
PGRMC2;
[6]
-
Membrane androgen receptors (mARs) –
GPRC6A,
OXER1,
ZIP9;
TRPM8;
[6]
Cav1.2
[6]
- Membrane corticosteroid receptors
In addition,
PDIA3 is a membrane receptor for the
secosteroid
calcitriol, the activated form of
Vitamin D.
[7]
-
^ Semicolons roughly denote structural groups, e.g. G-protein receptors from ion channels.
- ^
a
b Levin ER (2014).
"Translating extranuclear steroid receptor signaling to clinical medicine". Horm Cancer. 5 (3): 140–5.
doi:
10.1007/s12672-014-0179-9.
PMC
4040225.
PMID
24752388.
- ^
a
b Hammes SR, Levin ER (2011).
"Minireview: Recent advances in extranuclear steroid receptor actions". Endocrinology. 152 (12): 4489–95.
doi:
10.1210/en.2011-1470.
PMC
3858720.
PMID
22028449.
- ^
a
b Sen A, Prizant H, Hammes SR (2011).
"Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology". Steroids. 76 (9): 822–8.
doi:
10.1016/j.steroids.2011.02.016.
PMC
4972037.
PMID
21354434.
- ^
a
b Watson, C. S. (1999).
"Signaling Themes Shared Between Peptide and Steroid Hormones at the Plasma Membrane". Science Signaling. 1999 (12): pe1.
doi:
10.1126/stke.1999.12.pe1.
ISSN
1945-0877.
PMC
1317563.
PMID
11865187.
-
^ W.Norman, A.; Mizwicki, M. T.; Norman, D. G. (January 2004). "Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model". Nature Reviews Drug Discovery. 3 (1): 27–41.
doi:
10.1038/nrd1283.
PMID
14708019.
S2CID
17487277.
- ^
a
b
c
d
e
f
g Treviño, LS; Gorelick, DA (1 August 2021).
"The Interface of Nuclear and Membrane Steroid Signaling". Endocrinology. 162 (8): bqab107.
doi:
10.1210/endocr/bqab107.
PMC
8214340.
PMID
34038515.
-
^ Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, et al. (November 2016).
"Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957.
Bibcode:
2016NatSR...637957G.
doi:
10.1038/srep37957.
PMC
5126700.
PMID
27897272.