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From Wikipedia, the free encyclopedia

Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers. [1] They are used in the treatment of hypertension. [2]

Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls. [3]

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

Name Image Brand name Citations
Amlodipine
Norvasc, Istin, Normodipine, Tenox, Cordi Cor [4]
Aranidipine
Sapresta (サプレスタ) [5]
Azelnidipine
CalBlock (カルブロック) [6]
Barnidipine
Vasexten, Libradin, Cyress, HypoCa [7]
Benidipine
Coniel [8]
Cilnidipine
Atelec (アテレック), Cilacar, Cinalong, Siscard [9]
Clevidipine
Cleviprex [10]
Cronidipine
[11]
Darodipine
[12]
Dexniguldipine
[13]
Efonidipine
Landel (ランデル) [14]
Elgodipine
[15]
Elnadipine
[16]
Felodipine
Renedil, Plendil [17]
Flordipine
[18]
Furnidipine
[19]
Iganidipine
[20]
Isradipine
DynaCirc CR [21]
Lacidipine
Lacipil, Motens, Sakure
Lemildipine
Lercanidipine
Zanidip, Zanidip-Recordati
Levamlodipine
EsCordi Cor
Levniguldipine
Manidipine
Manyper, Caslot, Madipine
Nicardipine
Cardene, Cardene SR
Nifedipine
Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine
Nilvadipine
Nivadil
Nimodipine
Nimotop
Nisoldipine
Sular, Baymycard, Syscor
Nitrendipine
Baypress, Cardif, Nitrepin, Baylotensin
Olradipine
Oxodipine
Palonidipine
Pranidipine
Acalas
Ryodipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Vatanidipine

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid. [22]

See also

References

  1. ^ Bladen, Chris; Gündüz, Miyase Gözde; Şimşek, Rahime; Şafak, Cihat; Zamponi, Gerald W. (2014-10-23). "Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity". Pflügers Archiv: European Journal of Physiology. 466 (7): 1355–1363. doi: 10.1007/s00424-013-1376-z. ISSN  1432-2013. PMID  24149495. S2CID  253888496.
  2. ^ Xu, Lei; Li, Dan; Tao, Li; Yang, Yanling; Li, Youyong; Hou, Tingjun (2016). "Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study". Molecular BioSystems. 12 (2): 379–390. doi: 10.1039/c5mb00781j. ISSN  1742-2051. PMID  26673131.
  3. ^ Frishman, William H. (2007). "Calcium channel blockers: differences between subclasses". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 7 (Suppl 1): 17–23. doi: 10.2165/00129784-200707001-00003. ISSN  1175-3277. PMID  19845073. S2CID  21199295.
  4. ^ Bulsara, Kishen G.; Cassagnol, Manouchkathe (2022), "Amlodipine", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID  30137793, retrieved 2023-01-05
  5. ^ Okumura, K.; Ichihara, K.; Nagasaka, M. (1997). "Effects of aranidipine, a novel calcium channel blocker, on mechanical responses of the isolated rat portal vein: comparison with typical calcium channel blockers and potassium channel openers". Journal of Cardiovascular Pharmacology. 29 (2): 209–215. doi: 10.1097/00005344-199702000-00009. ISSN  0160-2446. PMID  9057070.
  6. ^ Wellington, Keri; Scott, Lesley J. (2003). "Azelnidipine". Drugs. 63 (23): 2613–2621, discussion 2623–2624. doi: 10.2165/00003495-200363230-00004. ISSN  0012-6667. PMID  14636080. S2CID  263994294.
  7. ^ Malhotra, H. S.; Plosker, G. L. (2001). "Barnidipine". Drugs. 61 (7): 989–996, discussion 997–998. doi: 10.2165/00003495-200161070-00007. ISSN  0012-6667. PMID  11434453. S2CID  263999687.
  8. ^ Opie, Lionel H. (2013-01-01), Opie, Lionel H.; Gersh, Bernard J. (eds.), "3 - Calcium channel blockers", Drugs for the Heart (Eighth Edition), Philadelphia: W.B. Saunders, pp. 64–92, ISBN  978-1-4557-3322-4, retrieved 2023-01-05
  9. ^ Shete, Mukesh Madhukar (2016). "Cilnidipine: Next Generation Calcium Channel Blocker". The Journal of the Association of Physicians of India. 64 (4): 95–99. ISSN  0004-5772. PMID  27734656.
  10. ^ Deeks, Emma D.; Keating, Gillian M.; Keam, Susan J. (2009). "Clevidipine: a review of its use in the management of acute hypertension". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 9 (2): 117–134. doi: 10.1007/BF03256583. ISSN  1175-3277. PMID  19331440.
  11. ^ PubChem. "Cronidipine". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-01-05.
  12. ^ Matucci, R.; Ottaviani, M. F.; Barbieri, M.; Cerbai, E.; Mugelli, A. (2009-02-12). "Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury". British Journal of Pharmacology. 122 (7): 1353–1360. doi: 10.1038/sj.bjp.0701525. ISSN  0007-1188. PMC  1565083. PMID  9421282.
  13. ^ Hahn, K. A.; Legendre, A. M.; Schuller, H. M. (1997). "Amputation and dexniguldipine as treatment for canine appendicular osteosarcoma". Journal of Cancer Research and Clinical Oncology. 123 (1): 34–38. doi: 10.1007/BF01212612. ISSN  0171-5216. PMID  8996538. S2CID  21129242.
  14. ^ Tanaka, Hikaru; Shigenobu, Koki (2002). "Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels". Cardiovascular Drug Reviews. 20 (1): 81–92. doi: 10.1111/j.1527-3466.2002.tb00084.x. ISSN  0897-5957. PMID  12070536.
  15. ^ Tamargo, J.; López-Sendón, J.; Delpón, E.; González-Morales, M.; de Miguel, E. (1991). "Cardiovascular effects of the new dihydropyridine derivative elgodipine". Arzneimittel-Forschung. 41 (9): 895–900. ISSN  0004-4172. PMID  1796916.
  16. ^ PubChem. "Elnadipine". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-01-05.
  17. ^ Bansal, Agam B.; Khandelwal, Gaurav (2022), "Felodipine", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID  31194320, retrieved 2023-01-05
  18. ^ Mayhan, W. G.; Heistad, D. D. (1985). "Effect of flordipine on cerebral blood flow". The Journal of Pharmacology and Experimental Therapeutics. 235 (1): 92–97. ISSN  0022-3565. PMID  4045730.
  19. ^ Krzemiński, Tadeusz F.; Hudziak, Damian; Sielańczyk, Andrzej W.; Porc, Maurycy; Kedzia, Agnieszka (2008). "Differential effects of furnidipine and its active metabolites in rat isolated working heart". Vascular Pharmacology. 49 (2–3): 91–96. doi: 10.1016/j.vph.2008.06.005. ISSN  1537-1891. PMID  18656554.
  20. ^ Ishii, Kiyoshi; Matsuo, Hiroshi; Fukaya, Yasuhiro; Tanaka, Sumiyoshi; Sakaki, Hideyuki; Waki, Mitsunori; Araie, Makoto (2003). "Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation". Investigative Ophthalmology & Visual Science. 44 (3): 1169–1177. doi: 10.1167/iovs.02-0482. ISSN  0146-0404. PMID  12601046.
  21. ^ Schachter, M. (1991). "Isradipine". Journal of Clinical Pharmacy and Therapeutics. 16 (2): 79–91. doi: 10.1111/j.1365-2710.1991.tb00288.x. ISSN  0269-4727. PMID  1830320. S2CID  221850085.
  22. ^ Tushar, Chopra; Okusa, Mark Douglas (2019-01-01), Ronco, Claudio; Bellomo, Rinaldo; Kellum, John A.; Ricci, Zaccaria (eds.), "Chapter 63 - Aldosterone Antagonists, Amiloride, and Triamterene", Critical Care Nephrology (Third Edition), Philadelphia: Elsevier, pp. 368–373.e1, ISBN  978-0-323-44942-7, retrieved 2023-01-05
Retrieved from " https://en.wikipedia.org/?title=Dihydropyridine_calcium_channel_blockers&oldid=1231006989"
From Wikipedia, the free encyclopedia

Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers. [1] They are used in the treatment of hypertension. [2]

Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls. [3]

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

Name Image Brand name Citations
Amlodipine
Norvasc, Istin, Normodipine, Tenox, Cordi Cor [4]
Aranidipine
Sapresta (サプレスタ) [5]
Azelnidipine
CalBlock (カルブロック) [6]
Barnidipine
Vasexten, Libradin, Cyress, HypoCa [7]
Benidipine
Coniel [8]
Cilnidipine
Atelec (アテレック), Cilacar, Cinalong, Siscard [9]
Clevidipine
Cleviprex [10]
Cronidipine
[11]
Darodipine
[12]
Dexniguldipine
[13]
Efonidipine
Landel (ランデル) [14]
Elgodipine
[15]
Elnadipine
[16]
Felodipine
Renedil, Plendil [17]
Flordipine
[18]
Furnidipine
[19]
Iganidipine
[20]
Isradipine
DynaCirc CR [21]
Lacidipine
Lacipil, Motens, Sakure
Lemildipine
Lercanidipine
Zanidip, Zanidip-Recordati
Levamlodipine
EsCordi Cor
Levniguldipine
Manidipine
Manyper, Caslot, Madipine
Nicardipine
Cardene, Cardene SR
Nifedipine
Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine
Nilvadipine
Nivadil
Nimodipine
Nimotop
Nisoldipine
Sular, Baymycard, Syscor
Nitrendipine
Baypress, Cardif, Nitrepin, Baylotensin
Olradipine
Oxodipine
Palonidipine
Pranidipine
Acalas
Ryodipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Vatanidipine

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid. [22]

See also

References

  1. ^ Bladen, Chris; Gündüz, Miyase Gözde; Şimşek, Rahime; Şafak, Cihat; Zamponi, Gerald W. (2014-10-23). "Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity". Pflügers Archiv: European Journal of Physiology. 466 (7): 1355–1363. doi: 10.1007/s00424-013-1376-z. ISSN  1432-2013. PMID  24149495. S2CID  253888496.
  2. ^ Xu, Lei; Li, Dan; Tao, Li; Yang, Yanling; Li, Youyong; Hou, Tingjun (2016). "Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study". Molecular BioSystems. 12 (2): 379–390. doi: 10.1039/c5mb00781j. ISSN  1742-2051. PMID  26673131.
  3. ^ Frishman, William H. (2007). "Calcium channel blockers: differences between subclasses". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 7 (Suppl 1): 17–23. doi: 10.2165/00129784-200707001-00003. ISSN  1175-3277. PMID  19845073. S2CID  21199295.
  4. ^ Bulsara, Kishen G.; Cassagnol, Manouchkathe (2022), "Amlodipine", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID  30137793, retrieved 2023-01-05
  5. ^ Okumura, K.; Ichihara, K.; Nagasaka, M. (1997). "Effects of aranidipine, a novel calcium channel blocker, on mechanical responses of the isolated rat portal vein: comparison with typical calcium channel blockers and potassium channel openers". Journal of Cardiovascular Pharmacology. 29 (2): 209–215. doi: 10.1097/00005344-199702000-00009. ISSN  0160-2446. PMID  9057070.
  6. ^ Wellington, Keri; Scott, Lesley J. (2003). "Azelnidipine". Drugs. 63 (23): 2613–2621, discussion 2623–2624. doi: 10.2165/00003495-200363230-00004. ISSN  0012-6667. PMID  14636080. S2CID  263994294.
  7. ^ Malhotra, H. S.; Plosker, G. L. (2001). "Barnidipine". Drugs. 61 (7): 989–996, discussion 997–998. doi: 10.2165/00003495-200161070-00007. ISSN  0012-6667. PMID  11434453. S2CID  263999687.
  8. ^ Opie, Lionel H. (2013-01-01), Opie, Lionel H.; Gersh, Bernard J. (eds.), "3 - Calcium channel blockers", Drugs for the Heart (Eighth Edition), Philadelphia: W.B. Saunders, pp. 64–92, ISBN  978-1-4557-3322-4, retrieved 2023-01-05
  9. ^ Shete, Mukesh Madhukar (2016). "Cilnidipine: Next Generation Calcium Channel Blocker". The Journal of the Association of Physicians of India. 64 (4): 95–99. ISSN  0004-5772. PMID  27734656.
  10. ^ Deeks, Emma D.; Keating, Gillian M.; Keam, Susan J. (2009). "Clevidipine: a review of its use in the management of acute hypertension". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 9 (2): 117–134. doi: 10.1007/BF03256583. ISSN  1175-3277. PMID  19331440.
  11. ^ PubChem. "Cronidipine". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-01-05.
  12. ^ Matucci, R.; Ottaviani, M. F.; Barbieri, M.; Cerbai, E.; Mugelli, A. (2009-02-12). "Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury". British Journal of Pharmacology. 122 (7): 1353–1360. doi: 10.1038/sj.bjp.0701525. ISSN  0007-1188. PMC  1565083. PMID  9421282.
  13. ^ Hahn, K. A.; Legendre, A. M.; Schuller, H. M. (1997). "Amputation and dexniguldipine as treatment for canine appendicular osteosarcoma". Journal of Cancer Research and Clinical Oncology. 123 (1): 34–38. doi: 10.1007/BF01212612. ISSN  0171-5216. PMID  8996538. S2CID  21129242.
  14. ^ Tanaka, Hikaru; Shigenobu, Koki (2002). "Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels". Cardiovascular Drug Reviews. 20 (1): 81–92. doi: 10.1111/j.1527-3466.2002.tb00084.x. ISSN  0897-5957. PMID  12070536.
  15. ^ Tamargo, J.; López-Sendón, J.; Delpón, E.; González-Morales, M.; de Miguel, E. (1991). "Cardiovascular effects of the new dihydropyridine derivative elgodipine". Arzneimittel-Forschung. 41 (9): 895–900. ISSN  0004-4172. PMID  1796916.
  16. ^ PubChem. "Elnadipine". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-01-05.
  17. ^ Bansal, Agam B.; Khandelwal, Gaurav (2022), "Felodipine", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID  31194320, retrieved 2023-01-05
  18. ^ Mayhan, W. G.; Heistad, D. D. (1985). "Effect of flordipine on cerebral blood flow". The Journal of Pharmacology and Experimental Therapeutics. 235 (1): 92–97. ISSN  0022-3565. PMID  4045730.
  19. ^ Krzemiński, Tadeusz F.; Hudziak, Damian; Sielańczyk, Andrzej W.; Porc, Maurycy; Kedzia, Agnieszka (2008). "Differential effects of furnidipine and its active metabolites in rat isolated working heart". Vascular Pharmacology. 49 (2–3): 91–96. doi: 10.1016/j.vph.2008.06.005. ISSN  1537-1891. PMID  18656554.
  20. ^ Ishii, Kiyoshi; Matsuo, Hiroshi; Fukaya, Yasuhiro; Tanaka, Sumiyoshi; Sakaki, Hideyuki; Waki, Mitsunori; Araie, Makoto (2003). "Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation". Investigative Ophthalmology & Visual Science. 44 (3): 1169–1177. doi: 10.1167/iovs.02-0482. ISSN  0146-0404. PMID  12601046.
  21. ^ Schachter, M. (1991). "Isradipine". Journal of Clinical Pharmacy and Therapeutics. 16 (2): 79–91. doi: 10.1111/j.1365-2710.1991.tb00288.x. ISSN  0269-4727. PMID  1830320. S2CID  221850085.
  22. ^ Tushar, Chopra; Okusa, Mark Douglas (2019-01-01), Ronco, Claudio; Bellomo, Rinaldo; Kellum, John A.; Ricci, Zaccaria (eds.), "Chapter 63 - Aldosterone Antagonists, Amiloride, and Triamterene", Critical Care Nephrology (Third Edition), Philadelphia: Elsevier, pp. 368–373.e1, ISBN  978-0-323-44942-7, retrieved 2023-01-05
Retrieved from " https://en.wikipedia.org/?title=Dihydropyridine_calcium_channel_blockers&oldid=1231006989"

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