From Wikipedia, the free encyclopedia
Isotetrahydrocannabinol
Identifiers
  • (1R,12R)-9-Methyl-5-pentyl-12-prop-1-en-2-yl-8-oxatricyclo[7.3.1.02,7]trideca-2,4,6-trien-3-ol
PubChem CID
Chemical and physical data
FormulaC21H30O2
Molar mass314.469 g·mol−1
3D model ( JSmol)
  • C=C(C)[C@@H]1CCC2(C)C[C@H]1c1c(cc(CCCCC)cc1O)O2

Isotetrahydrocannabinol (iso-THC) is a phytocannabinoid similar in structure to cannabicitran which has been identified as a trace component of Cannabis, but is more commonly found as an impurity in synthetic THC which has been made from cannabidiol. iso-THC is present with other isomers with the double bond in a different position and the saturated dihydro derivative. iso-THC can be described as the upper cyclization product of CBD, while THC is the lower cyclization product of CBD. Its pharmacology has not been studied, though it is commonly found as a trace impurity in commercially marketed Δ8-THC products. [1] [2] [3] [4]

See also

References

  1. ^ Marzullo P, Foschi F, Coppini DA, Fanchini F, Magnani L, Rusconi S, et al. (October 2020). "Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization". Journal of Natural Products. 83 (10): 2894–2901. doi: 10.1021/acs.jnatprod.0c00436. PMC  8011986. PMID  32991167.
  2. ^ Nguyen GN, Jordan EN, Kayser O (June 2022). "Synthetic Strategies for Rare Cannabinoids Derived from Cannabis sativa". Journal of Natural Products. 85 (6): 1555–1568. doi: 10.1021/acs.jnatprod.2c00155. PMID  35648593. S2CID  249234673.
  3. ^ Radwan MM, Wanas AS, Gul W, Ibrahim EA, ElSohly MA (April 2023). "Isolation and Characterization of Impurities in Commercially Marketed Δ8-THC Products". Journal of Natural Products. 86 (4): 822–829. doi: 10.1021/acs.jnatprod.2c01008. PMID  36827690. S2CID  257183893.
  4. ^ Tanaka R, Kikura-Hanajiri R (June 2023). "Identification of hexahydrocannabinol (HHC), dihydro-iso-tetrahydrocannabinol (dihydro-iso-THC) and hexahydrocannabiphorol (HHCP) in electronic cigarette cartridge products". Forensic Toxicology. doi: 10.1007/s11419-023-00667-9. PMID  37365398. S2CID  259259903.


From Wikipedia, the free encyclopedia
Isotetrahydrocannabinol
Identifiers
  • (1R,12R)-9-Methyl-5-pentyl-12-prop-1-en-2-yl-8-oxatricyclo[7.3.1.02,7]trideca-2,4,6-trien-3-ol
PubChem CID
Chemical and physical data
FormulaC21H30O2
Molar mass314.469 g·mol−1
3D model ( JSmol)
  • C=C(C)[C@@H]1CCC2(C)C[C@H]1c1c(cc(CCCCC)cc1O)O2

Isotetrahydrocannabinol (iso-THC) is a phytocannabinoid similar in structure to cannabicitran which has been identified as a trace component of Cannabis, but is more commonly found as an impurity in synthetic THC which has been made from cannabidiol. iso-THC is present with other isomers with the double bond in a different position and the saturated dihydro derivative. iso-THC can be described as the upper cyclization product of CBD, while THC is the lower cyclization product of CBD. Its pharmacology has not been studied, though it is commonly found as a trace impurity in commercially marketed Δ8-THC products. [1] [2] [3] [4]

See also

References

  1. ^ Marzullo P, Foschi F, Coppini DA, Fanchini F, Magnani L, Rusconi S, et al. (October 2020). "Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization". Journal of Natural Products. 83 (10): 2894–2901. doi: 10.1021/acs.jnatprod.0c00436. PMC  8011986. PMID  32991167.
  2. ^ Nguyen GN, Jordan EN, Kayser O (June 2022). "Synthetic Strategies for Rare Cannabinoids Derived from Cannabis sativa". Journal of Natural Products. 85 (6): 1555–1568. doi: 10.1021/acs.jnatprod.2c00155. PMID  35648593. S2CID  249234673.
  3. ^ Radwan MM, Wanas AS, Gul W, Ibrahim EA, ElSohly MA (April 2023). "Isolation and Characterization of Impurities in Commercially Marketed Δ8-THC Products". Journal of Natural Products. 86 (4): 822–829. doi: 10.1021/acs.jnatprod.2c01008. PMID  36827690. S2CID  257183893.
  4. ^ Tanaka R, Kikura-Hanajiri R (June 2023). "Identification of hexahydrocannabinol (HHC), dihydro-iso-tetrahydrocannabinol (dihydro-iso-THC) and hexahydrocannabiphorol (HHCP) in electronic cigarette cartridge products". Forensic Toxicology. doi: 10.1007/s11419-023-00667-9. PMID  37365398. S2CID  259259903.



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