Isotetrahydrocannabinol (iso-THC) is a
phytocannabinoid similar in structure to
cannabicitran which has been identified as a trace component of Cannabis, but is more commonly found as an impurity in synthetic
THC which has been made from
cannabidiol. iso-THC is present with other isomers with the double bond in a different position and the saturated dihydro derivative. iso-THC can be described as the upper cyclization product of CBD, while THC is the lower cyclization product of CBD. Its pharmacology has not been studied, though it is commonly found as a trace impurity in commercially marketed Δ8-THC products.[1][2][3][4]
^Nguyen GN, Jordan EN, Kayser O (June 2022). "Synthetic Strategies for Rare Cannabinoids Derived from Cannabis sativa". Journal of Natural Products. 85 (6): 1555–1568.
doi:
10.1021/acs.jnatprod.2c00155.
PMID35648593.
S2CID249234673.
^Radwan MM, Wanas AS, Gul W, Ibrahim EA, ElSohly MA (April 2023). "Isolation and Characterization of Impurities in Commercially Marketed Δ8-THC Products". Journal of Natural Products. 86 (4): 822–829.
doi:
10.1021/acs.jnatprod.2c01008.
PMID36827690.
S2CID257183893.
^Tanaka R, Kikura-Hanajiri R (June 2023). "Identification of hexahydrocannabinol (HHC), dihydro-iso-tetrahydrocannabinol (dihydro-iso-THC) and hexahydrocannabiphorol (HHCP) in electronic cigarette cartridge products". Forensic Toxicology.
doi:
10.1007/s11419-023-00667-9.
PMID37365398.
S2CID259259903.
Isotetrahydrocannabinol (iso-THC) is a
phytocannabinoid similar in structure to
cannabicitran which has been identified as a trace component of Cannabis, but is more commonly found as an impurity in synthetic
THC which has been made from
cannabidiol. iso-THC is present with other isomers with the double bond in a different position and the saturated dihydro derivative. iso-THC can be described as the upper cyclization product of CBD, while THC is the lower cyclization product of CBD. Its pharmacology has not been studied, though it is commonly found as a trace impurity in commercially marketed Δ8-THC products.[1][2][3][4]
^Nguyen GN, Jordan EN, Kayser O (June 2022). "Synthetic Strategies for Rare Cannabinoids Derived from Cannabis sativa". Journal of Natural Products. 85 (6): 1555–1568.
doi:
10.1021/acs.jnatprod.2c00155.
PMID35648593.
S2CID249234673.
^Radwan MM, Wanas AS, Gul W, Ibrahim EA, ElSohly MA (April 2023). "Isolation and Characterization of Impurities in Commercially Marketed Δ8-THC Products". Journal of Natural Products. 86 (4): 822–829.
doi:
10.1021/acs.jnatprod.2c01008.
PMID36827690.
S2CID257183893.
^Tanaka R, Kikura-Hanajiri R (June 2023). "Identification of hexahydrocannabinol (HHC), dihydro-iso-tetrahydrocannabinol (dihydro-iso-THC) and hexahydrocannabiphorol (HHCP) in electronic cigarette cartridge products". Forensic Toxicology.
doi:
10.1007/s11419-023-00667-9.
PMID37365398.
S2CID259259903.