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Clinical data | |
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Other names | 2-indanylamine; 2-indanamine |
Routes of administration | Oral |
ATC code |
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CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.019.111 |
Chemical and physical data | |
Formula | C9H11N |
Molar mass | 133.194 g·mol−1 |
3D model ( JSmol) | |
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2-Aminoindane (2-AI) is a research chemical with applications in neurologic disorders and psychotherapy that has also been sold as a designer drug. [1] It acts as a selective substrate for NET and DAT. [2] [3]
Synthetic aminoindanes were originally developed in the context of anti-Parkinsonian drugs as a metabolite of rasagiline and as a tool to be used in psychotherapy. Deaths related to their toxic effects have been observed both in the laboratory in animal studies and in clinical encounters. [4] 2-AI is a rigid analogue of amphetamine and partially substitutes for it in rat discrimination tests. [5]
There are a number of derivatives of 2-aminoindane and its positional isomer 1-aminoindane exist, including:
As of October 2015 2-AI is a controlled substance in China. [6]
Sweden's public health agency suggested classifying 2-AI as a hazardous substance, on June 24, 2019. [7]
2-Aminoindane is not scheduled at the federal level in the United States, [8] but may be considered an analog of amphetamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.
![]() | |
![]() | |
Clinical data | |
---|---|
Other names | 2-indanylamine; 2-indanamine |
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.019.111 |
Chemical and physical data | |
Formula | C9H11N |
Molar mass | 133.194 g·mol−1 |
3D model ( JSmol) | |
| |
| |
![]() ![]() |
2-Aminoindane (2-AI) is a research chemical with applications in neurologic disorders and psychotherapy that has also been sold as a designer drug. [1] It acts as a selective substrate for NET and DAT. [2] [3]
Synthetic aminoindanes were originally developed in the context of anti-Parkinsonian drugs as a metabolite of rasagiline and as a tool to be used in psychotherapy. Deaths related to their toxic effects have been observed both in the laboratory in animal studies and in clinical encounters. [4] 2-AI is a rigid analogue of amphetamine and partially substitutes for it in rat discrimination tests. [5]
There are a number of derivatives of 2-aminoindane and its positional isomer 1-aminoindane exist, including:
As of October 2015 2-AI is a controlled substance in China. [6]
Sweden's public health agency suggested classifying 2-AI as a hazardous substance, on June 24, 2019. [7]
2-Aminoindane is not scheduled at the federal level in the United States, [8] but may be considered an analog of amphetamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.