Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an
enzyme that in humans is encoded by the EIF2AK3gene.[5][6][7][8]
Function
The protein encoded by this gene
phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (
EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the
endoplasmic reticulum (ER), where it is induced by ER stress caused by
malfolded proteins.[6]
^Hayes SE, Conner LJ, Stramm LE, Shi Y (1999). "Assignment of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization". Cytogenetics and Cell Genetics. 86 (3–4): 327–328.
doi:
10.1159/000015328.
PMID10575235.
S2CID84483593.
^Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (June 2000). "Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response". Nature Cell Biology. 2 (6): 326–332.
doi:
10.1038/35014014.
PMID10854322.
S2CID22684712.
Further reading
Mellor H, Proud CG (July 1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochemical and Biophysical Research Communications. 178 (2): 430–437.
doi:
10.1016/0006-291X(91)90125-Q.
PMID1677563.
Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, et al. (December 2004). "The EIF2AK3 gene region and type I diabetes in subjects from South India". Genes and Immunity. 5 (8): 648–652.
doi:
10.1038/sj.gene.6364139.
PMID15483661.
S2CID21566833.
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an
enzyme that in humans is encoded by the EIF2AK3gene.[5][6][7][8]
Function
The protein encoded by this gene
phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (
EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the
endoplasmic reticulum (ER), where it is induced by ER stress caused by
malfolded proteins.[6]
^Hayes SE, Conner LJ, Stramm LE, Shi Y (1999). "Assignment of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization". Cytogenetics and Cell Genetics. 86 (3–4): 327–328.
doi:
10.1159/000015328.
PMID10575235.
S2CID84483593.
^Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (June 2000). "Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response". Nature Cell Biology. 2 (6): 326–332.
doi:
10.1038/35014014.
PMID10854322.
S2CID22684712.
Further reading
Mellor H, Proud CG (July 1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochemical and Biophysical Research Communications. 178 (2): 430–437.
doi:
10.1016/0006-291X(91)90125-Q.
PMID1677563.
Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, et al. (December 2004). "The EIF2AK3 gene region and type I diabetes in subjects from South India". Genes and Immunity. 5 (8): 648–652.
doi:
10.1038/sj.gene.6364139.
PMID15483661.
S2CID21566833.