From Wikipedia, the free encyclopedia
The lysophosphatidic acid receptors (LPARs) are a group of
G protein-coupled receptors for
lysophosphatidic acid (LPA) that include:
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Extracellular | Eicosanoids | |
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Lysophospholipids | |
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Steroids | |
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Others | |
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Intracellular |
Nuclear receptor | |
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Second messenger |
- General:
Arachidonic acid
-
DAG (
PKC,
TRPC)
-
IP3 (
IP3R,
RyR)
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Phosphatidic acid
- Phosphoinositides:
PIP2 (
IRKs)
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PIP3 (
PKB/Akt,
Btk,
PDPK1)
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PtdIns(3,4)P2 (
PKB/Akt,
PDPK1); Sphingolipids:
C1P
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Ceramide (
CAPPs,
KSR1,
PKCζ,
CTSD)
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Glucosylceramides
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S1P
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Sphingosine (
SDK1,
PKH,
YPK)
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Precursors | |
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