Homatropine methylbromide (
INN; also known as methylhomatropine bromide) is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting
anticholinergicmedication that inhibits
muscarinic acetylcholine receptors and thus the
parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics.[1]
It is used, in addition to
papaverine, as a component of mild drugs that help "flush" the
bile.
Certain preparations of drugs such as
hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.[2]
Homatropine methylbromide (
INN; also known as methylhomatropine bromide) is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting
anticholinergicmedication that inhibits
muscarinic acetylcholine receptors and thus the
parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics.[1]
It is used, in addition to
papaverine, as a component of mild drugs that help "flush" the
bile.
Certain preparations of drugs such as
hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.[2]