From Wikipedia, the free encyclopedia
Protein family
Glycine transporters (GlyTs) are
plasmalemmal
neurotransmitter transporters. They serve to terminate the signaling of
glycine by mediating its
reuptake from the
synaptic cleft back into the
presynaptic
neurons. There are two glycine transporters:
glycine transporter 1 (GlyT1) and
glycine transporter 2 (GlyT2).
[1]
See also
References
-
^ Harvey RJ, Yee BK (November 2013). "Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain". Nat Rev Drug Discov. 12 (11): 866–85.
doi:
10.1038/nrd3893.
PMID
24172334.
S2CID
28022131.
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SLC1–10 |
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| SLC21–30 |
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| SLC31–40 |
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| SLC41–48 |
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Receptor (
ligands) |
GlyRTooltip Glycine receptor |
- Positive modulators:
Alcohols (e.g.,
brometone,
chlorobutanol (chloretone),
ethanol (alcohol),
tert-butanol (2M2P),
tribromoethanol,
trichloroethanol,
trifluoroethanol)
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Alkylbenzene sulfonate
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Anandamide
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Barbiturates (e.g.,
pentobarbital,
sodium thiopental)
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Chlormethiazole
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D12-116
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Dihydropyridines (e.g.,
nicardipine)
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Etomidate
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Ginseng constituents (e.g.,
ginsenosides (e.g.,
ginsenoside-Rf))
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Glutamic acid (glutamate)
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Ivermectin
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Ketamine
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Neuroactive steroids (e.g.,
alfaxolone,
pregnenolone (eltanolone),
pregnenolone acetate,
minaxolone,
ORG-20599)
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Nitrous oxide
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Penicillin G
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Propofol
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Tamoxifen
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Tetrahydrocannabinol
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Triclofos
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Tropeines (e.g.,
atropine,
bemesetron,
cocaine,
LY-278584,
tropisetron,
zatosetron)
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Volatiles/
gases (e.g.,
chloral hydrate,
chloroform,
desflurane,
diethyl ether (ether),
enflurane,
halothane,
isoflurane,
methoxyflurane,
sevoflurane,
toluene,
trichloroethane (methyl chloroform),
trichloroethylene)
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Xenon
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Zinc
- Antagonists:
2-Aminostrychnine
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2-Nitrostrychnine
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4-Phenyl-4-formyl-N-methylpiperidine
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αEMBTL
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Bicuculline
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Brucine
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Cacotheline
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Caffeine
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Colchicine
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Colubrine
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Cyanotriphenylborate
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Dendrobine
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Diaboline
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Endocannabinoids (e.g.,
2-AG,
anandamide (AEA))
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Gaboxadol (THIP)
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Gelsemine
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iso-THAZ
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Isobutyric acid
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Isonipecotic acid
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Isostrychnine
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Laudanosine
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N-Methylbicuculline
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N-Methylstrychnine
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N,N-Dimethylmuscimol
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Nipecotic acid
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Pitrazepin
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Pseudostrychnine
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Quinolines (e.g.,
4-hydroxyquinoline,
4-hydroxyquinoline-3-carboxylic acid,
5,7-CIQA,
7-CIQ,
7-TFQ,
7-TFQA)
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RU-5135
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Sinomenine
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Strychnine
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Thiocolchicoside
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Tutin
- Negative modulators:
Amiloride
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Benzodiazepines (e.g.,
bromazepam,
clonazepam,
diazepam,
flunitrazepam,
flurazepam)
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Corymine
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Cyanotriphenylborate
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Daidzein
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Dihydropyridines (e.g.,
nicardipine,
nifedipine,
nitrendipine)
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Furosemide
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Genistein
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Ginkgo constituents (e.g.,
bilobalide,
ginkgolides (e.g.,
ginkgolide A,
ginkgolide B,
ginkgolide C,
ginkgolide J,
ginkgolide M))
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Imipramine
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NBQX
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Neuroactive steroids (e.g.,
3α-androsterone sulfate,
3β-androsterone sulfate,
deoxycorticosterone,
DHEA sulfate,
pregnenolone sulfate,
progesterone)
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Opioids (e.g.,
codeine,
dextromethorphan,
dextrorphan,
levomethadone,
levorphanol,
morphine,
oripavine,
pethidine,
thebaine)
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Picrotoxin (i.e.,
picrotin and
picrotoxinin)
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PMBA
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Riluzole
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Tropeines (e.g.,
bemesetron,
LY-278584,
tropisetron,
zatosetron)
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Verapamil
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Zinc
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NMDARTooltip N-Methyl-D-aspartate receptor | |
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Transporter (
blockers) |
GlyT1Tooltip Glycine transporter 1 | |
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GlyT2Tooltip Glycine transporter 2 | |
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