VESICULAR GLUTAMATE TRANSPORTER 1

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208; MGI: 1920211; HomoloGene: 113454; GeneCards: SLC17A7; OMA: SLC17A7 - orthologs
Gene location ( Human)
Chr.	Chromosome 19 (human)
End	49,442,360 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	44,825,566 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; superior frontal gyrus; ; Brodmann area 10; ; frontal pole; ; Region I of hippocampus proper; ; middle temporal gyrus; ; Brodmann area 46; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; prefrontal cortex; ; piriform cortex; ; cerebellar cortex; ; hippocampus proper; ; primary motor cortex; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	inorganic phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; extracellularly glutamate-gated chloride channel activity; symporter activity; L-glutamate transmembrane transporter activity; neurotransmitter transmembrane transporter activity;
Cellular component	postsynapse; integral component of membrane; membrane; synaptic vesicle; plasma membrane; synapse; excitatory synapse; synaptic vesicle membrane; cerebellar mossy fiber; presynaptic active zone; cell junction; intracellular organelle; neuron projection; clathrin-sculpted glutamate transport vesicle membrane; cytoplasmic vesicle; integral component of synaptic vesicle membrane;
Biological process	phosphate ion transport; synaptic transmission, glutamatergic; sodium-dependent phosphate transport; sodium ion transport; chloride transmembrane transport; ion transport; glutamate secretion; synaptic vesicle lumen acidification; brain development; long-term memory; excitatory postsynaptic potential; neurotransmitter transport; neural retina development; L-glutamate import; sequestering of neurotransmitter; sodium ion transmembrane transport; transmembrane transport; chemical synaptic transmission; neurotransmitter loading into synaptic vesicle; L-glutamate transmembrane transport; regulation of synaptic vesicle endocytosis; regulation of synapse structure or activity;
	Sources: Amigo / QuickGO
Orthologs
	57030
	72961
	ENSG00000104888
	ENSMUSG00000070570
	Q9P2U7
	Q3TXX4
	NM_020309
	NM_182993
	NP_064705
	NP_892038
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^[5]^[6]^[7]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi: 10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.
^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi: 10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.
^ ^a ^b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. Bibcode: 2000Sci...289..957B. doi: 10.1126/science.289.5481.957. PMID 10938000.
Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. Bibcode: 2000Natur.407..189T. doi: 10.1038/35025070. hdl: 11858/00-001M-0000-0012-F987-C. PMID 11001057. S2CID 4412622.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi: 10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi: 10.1016/j.neuroscience.2005.03.038. PMID 15961236. S2CID 25943855.
Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi: 10.1111/j.1471-4159.2006.03821.x. PMID 16606361. S2CID 3133505.
Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi: 10.1110/ps.072944707. PMC 2206968. PMID 17660252.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8632143-5] Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi: 10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.

[pmid10820226-6] Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi: 10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.

[entrez-7] "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

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