The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of
sodium–hydrogen antiporter that in humans is encoded by the SLC9A1gene.[5]
Function
The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug
amiloride and activated by a variety of signals including
growth factors,
mitogens,
neurotransmitters,
tumor promoters, and others.[6]
Dudley CR, Giuffra LA, Tippett P, Kidd KK, Reeders ST (November 1990). "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1". Human Genetics. 86 (1): 79–83.
doi:
10.1007/bf00205179.
PMID1979310.
S2CID20107780.
Sardet C, Counillon L, Franchi A, Pouysségur J (February 1990). "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD". Science. 247 (4943): 723–6.
Bibcode:
1990Sci...247..723S.
doi:
10.1126/science.2154036.
PMID2154036.
Sardet C, Franchi A, Pouysségur J (January 1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell. 56 (2): 271–80.
doi:
10.1016/0092-8674(89)90901-X.
PMID2536298.
S2CID2782563.
Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenetics and Cell Genetics. 48 (1): 6–8.
doi:
10.1159/000132575.
PMID2846238.
Counillon L, Pouysségur J, Reithmeier RA (August 1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry. 33 (34): 10463–9.
doi:
10.1021/bi00200a030.
PMID8068684.
Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Molecular and Cellular Biochemistry. 125 (2): 137–43.
doi:
10.1007/BF00936442.
PMID8283968.
S2CID24360200.
The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of
sodium–hydrogen antiporter that in humans is encoded by the SLC9A1gene.[5]
Function
The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug
amiloride and activated by a variety of signals including
growth factors,
mitogens,
neurotransmitters,
tumor promoters, and others.[6]
Dudley CR, Giuffra LA, Tippett P, Kidd KK, Reeders ST (November 1990). "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1". Human Genetics. 86 (1): 79–83.
doi:
10.1007/bf00205179.
PMID1979310.
S2CID20107780.
Sardet C, Counillon L, Franchi A, Pouysségur J (February 1990). "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD". Science. 247 (4943): 723–6.
Bibcode:
1990Sci...247..723S.
doi:
10.1126/science.2154036.
PMID2154036.
Sardet C, Franchi A, Pouysségur J (January 1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell. 56 (2): 271–80.
doi:
10.1016/0092-8674(89)90901-X.
PMID2536298.
S2CID2782563.
Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenetics and Cell Genetics. 48 (1): 6–8.
doi:
10.1159/000132575.
PMID2846238.
Counillon L, Pouysségur J, Reithmeier RA (August 1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry. 33 (34): 10463–9.
doi:
10.1021/bi00200a030.
PMID8068684.
Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Molecular and Cellular Biochemistry. 125 (2): 137–43.
doi:
10.1007/BF00936442.
PMID8283968.
S2CID24360200.