From Wikipedia, the free encyclopedia
Protein found in humans
Zinc transporter 3 also known as solute carrier family 30 member 3 is a
protein in humans that is encoded by the SLC30A3
gene.
[5]
The SLC30A3 gene codes for the ZnT-3
SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of
zinc ions inside
synaptic vesicles.
[6] In mice, ZnT-3 is required for some forms of memory that depend on the
hippocampus and the
amygdala.
[7] Zinc transport by ZnT-3 modulates memory formation by acting through the
extracellular signal-regulated kinases signaling pathway.
[8]
Angiotensin II-induced senescence of
vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.
[9]
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000115194 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000029151 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Entrez Gene: Solute carrier family 30 (zinc transporter), member 3".
-
^ Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD (February 1999).
"Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1716–21.
Bibcode:
1999PNAS...96.1716C.
doi:
10.1073/pnas.96.4.1716.
PMC
15571.
PMID
9990090.
-
^ Sindreu C, Storm DR (2011).
"Modulation of neuronal signal transduction and memory formation by synaptic zinc". Frontiers in Behavioral Neuroscience. 5: 68.
doi:
10.3389/fnbeh.2011.00068.
PMC
3211062.
PMID
22084630.
-
^ Mott DD, Dingledine R (February 2011).
"Unraveling the role of zinc in memory". Proceedings of the National Academy of Sciences of the United States of America. 108 (8): 3103–4.
Bibcode:
2011PNAS..108.3103M.
doi:
10.1073/pnas.1100323108.
PMC
3044369.
PMID
21321213.
-
^ Patrushev N, Seidel-Rogol B, Salazar G (2012).
"Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLOS ONE. 7 (3): e33211.
Bibcode:
2012PLoSO...733211P.
doi:
10.1371/journal.pone.0033211.
PMC
3299759.
PMID
22427991.
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SLC1–10 |
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| SLC21–30 |
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| SLC41–48 |
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