SLC25A4

SLC25A4
Identifiers
Aliases	SLC25A4, AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, T1, PEOA2, solute carrier family 25 member 4, MTDPS12A
External IDs	OMIM: 103220; MGI: 1353495; HomoloGene: 36058; GeneCards: SLC25A4; OMA: SLC25A4 - orthologs
Gene location ( Human)
Chr.	Chromosome 4 (human)
End	185,150,382 bp
Gene location ( Mouse)
Chr.	Chromosome 8 (mouse)
End	46,664,321 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; apex of heart; ; cardiac muscle tissue of right atrium; ; body of tongue; ; triceps brachii muscle; ; vastus lateralis muscle; ; thoracic diaphragm; ; right auricle; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	atrioventricular valve; ; endocardial cushion; ; atrium; ; myocardium of ventricle; ; cardiac muscles; ; gastrocnemius muscle; ; plantaris muscle; ; extensor digitorum longus muscle; ; interventricular septum; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; adenine transmembrane transporter activity; ATP:ADP antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; myelin sheath; integral component of plasma membrane; mitochondrion; nucleus; mitochondrial inner membrane; integral component of mitochondrial membrane;
Biological process	mitochondrial genome maintenance; regulation of insulin secretion; negative regulation of necroptotic process; generation of precursor metabolites and energy; apoptotic mitochondrial changes; transmembrane transport; viral process; adenine transport; ATP transport; regulation of mitochondrial membrane permeability; ADP transport; transport;
	Sources: Amigo / QuickGO
Orthologs
	291
	11739
	ENSG00000151729
	ENSMUSG00000031633
	P12235
	P48962
	NM_001151
	NM_007450
	NP_001142
	NP_031476
	Wikidata
View/Edit Human	View/Edit Mouse

ADP/ATP translocase 1, or adenine nucleotide translocator 1 (ANT1), is an enzyme that in humans is encoded by the SLC25A4 gene.^[5]^[6]

Interactions

SLC25A4 has been shown to interact with Bcl-2-associated X protein.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151729 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031633 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fan YS, Yang HM, Lin CC (June 1992). "Assignment of the human muscle adenine nucleotide translocator gene (ANT1) to 4q35 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 60 (1): 29–30. doi: 10.1159/000133288. PMID 1582253.
^ "Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4".
^ Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (September 1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027–31. Bibcode: 1998Sci...281.2027M. doi: 10.1126/science.281.5385.2027. PMID 9748162.

Vieira HL, Haouzi D, El Hamel C, Jacotot E, Belzacq AS, Brenner C, Kroemer G (December 2000). "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator". Cell Death and Differentiation. 7 (12): 1146–54. doi: 10.1038/sj.cdd.4400778. PMID 11175251.
Ferri KF, Jacotot E, Blanco J, Esté JA, Kroemer G (2001). "Mitochondrial control of cell death induced by HIV-1-encoded proteins". Annals of the New York Academy of Sciences. 926: 149–64. doi: 10.1111/j.1749-6632.2000.tb05609.x. PMID 11193032. S2CID 21997163.
Kino T, Pavlakis GN (April 2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA and Cell Biology. 23 (4): 193–205. doi: 10.1089/104454904773819789. PMID 15142377.
Andersen JL, Planelles V (January 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research. 3 (1): 43–51. doi: 10.2174/1570162052772988. PMID 15638722.
Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi: 10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
Zhao RY, Bukrinsky M, Elder RT (April 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, Weiner DB (August 2005). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism". Cell Death and Differentiation. 12 (Suppl 1): 962–70. doi: 10.1038/sj.cdd.4401583. PMID 15832179.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi: 10.1038/sj.cr.7290370. PMID 16354571.
Moon HS, Yang JS (February 2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Molecules and Cells. 21 (1): 7–20. doi: 10.1016/s1016-8478(23)12897-4. PMID 16511342.
Cozens AL, Runswick MJ, Walker JE (March 1989). "DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase". Journal of Molecular Biology. 206 (2): 261–80. doi: 10.1016/0022-2836(89)90477-4. PMID 2541251.
Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Wallace DC (August 1989). "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed". The Journal of Biological Chemistry. 264 (24): 13998–4004. doi: 10.1016/S0021-9258(18)71632-3. PMID 2547778.
Neckelmann N, Li K, Wade RP, Shuster R, Wallace DC (November 1987). "cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes". Proceedings of the National Academy of Sciences of the United States of America. 84 (21): 7580–4. Bibcode: 1987PNAS...84.7580N. doi: 10.1073/pnas.84.21.7580. PMC 299343. PMID 2823266.
Houldsworth J, Attardi G (January 1988). "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver". Proceedings of the National Academy of Sciences of the United States of America. 85 (2): 377–81. Bibcode: 1988PNAS...85..377H. doi: 10.1073/pnas.85.2.377. PMC 279551. PMID 2829183.
Wijmenga C, Winokur ST, Padberg GW, Skraastad MI, Altherr MR, Wasmuth JJ, Murray JC, Hofker MH, Frants RR (September 1993). "The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus". Human Genetics. 92 (2): 198–203. doi: 10.1007/BF00219692. PMID 8103757. S2CID 19879528.
Bakker HD, Scholte HR, Van den Bogert C, Ruitenbeek W, Jeneson JA, Wanders RJ, Abeling NG, Dorland B, Sengers RC, Van Gennip AH (April 1993). "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect". Pediatric Research. 33 (4 Pt 1): 412–7. doi: 10.1203/00006450-199304000-00019. PMID 8479824.
Kaukonen JA, Amati P, Suomalainen A, Rötig A, Piscaglia MG, Salvi F, Weissenbach J, Fratta G, Comi G, Peltonen L, Zeviani M (April 1996). "An autosomal locus predisposing to multiple deletions of mtDNA on chromosome 3p". American Journal of Human Genetics. 58 (4): 763–9. PMC 1914672. PMID 8644740.
Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (September 1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027–31. Bibcode: 1998Sci...281.2027M. doi: 10.1126/science.281.5385.2027. PMID 9748162.
Kaukonen J, Zeviani M, Comi GP, Piscaglia MG, Peltonen L, Suomalainen A (July 1999). "A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia". American Journal of Human Genetics. 65 (1): 256–61. doi: 10.1086/302445. PMC 1378100. PMID 10364542.
Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HL, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand JP, Irinopoulou T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP, Kroemer G (January 2000). "The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore". The Journal of Experimental Medicine. 191 (1): 33–46. doi: 10.1084/jem.191.1.33. PMC 2195797. PMID 10620603.
Wang, X., Middleton, F. A., Tawil, R., & Chen, X. J. (2020). "Cytosolic Adaptation to Mitochondrial Precursor Overaccumulation Stress Induces Progressive Muscle Wasting". bioRxiv, 733097. https://doi.org/10.1101/733097

External links

SLC25A4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151729 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031633 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1582253-5] Fan YS, Yang HM, Lin CC (June 1992). "Assignment of the human muscle adenine nucleotide translocator gene (ANT1) to 4q35 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 60 (1): 29–30. doi: 10.1159/000133288. PMID 1582253.

[entrez-6] "Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4".

[pmid9748162-7] Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (September 1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027–31. Bibcode: 1998Sci...281.2027M. doi: 10.1126/science.281.5385.2027. PMID 9748162.

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