The ITGB3 protein product is the integrin beta chain beta 3.
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[7]
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of
endometriosis, and has been suggested as a putative marker of this condition.[8]
Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187–93.
doi:
10.1055/s-0037-1612971.
PMID11858476.
Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22.
PMID12690916.
Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res. 112 (4): 209–16.
doi:
10.1016/j.thromres.2003.11.010.
PMID14987913.
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76.
doi:
10.2174/1381612043384682.
PMID15134555.
The ITGB3 protein product is the integrin beta chain beta 3.
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[7]
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of
endometriosis, and has been suggested as a putative marker of this condition.[8]
Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187–93.
doi:
10.1055/s-0037-1612971.
PMID11858476.
Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22.
PMID12690916.
Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res. 112 (4): 209–16.
doi:
10.1016/j.thromres.2003.11.010.
PMID14987913.
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76.
doi:
10.2174/1381612043384682.
PMID15134555.