β-Thromboglobulin | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CXCL7 | ||||||
Alt. symbols | CTAP3, CXCL7, SCYB7, TGB1, THBGB1 | ||||||
NCBI gene | 5473 | ||||||
HGNC | 9240 | ||||||
OMIM | 121010 | ||||||
RefSeq | NP_002695 | ||||||
UniProt | P02775 | ||||||
Other data | |||||||
Locus | Chr. 4 q13.3 | ||||||
|
β-Thromboglobulin (β-TG), or beta-thromboglobulin, is a chemokine protein secreted by platelets. [1] [2] It is a type of chemokine (C-X-C motif) ligand 7. [3] Along with platelet factor 4 (PF4), β-TG is one of the best-characterized platelet-specific proteins. [4] β-TG and PF4 are stored in platelet alpha granules and are released during platelet activation. [1] [4] [5] As a result, they are useful markers of platelet activation. [1] [4] β-TG also has multiple biological activities, for instance being involved in maturation of megakaryocytes. [6]
β-TG is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts. [5]
β-TG also affects megakaryocyte maturation, and thus helps in regulating platelet production. [5]
Levels of β-TG is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with PF4. [5]
β-TG levels may increase with age. [7] It is elevated in diabetes mellitus. [8]
β-TG levels have been found to be increased by treatment with the synthetic estrogen ethinylestradiol, though were not significantly increased by the natural estrogen estradiol valerate. [9] [10] [11] [12] Levels of β-TG have also been found to be increased or unchanged during normal pregnancy. [13]
β-Thromboglobulin | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CXCL7 | ||||||
Alt. symbols | CTAP3, CXCL7, SCYB7, TGB1, THBGB1 | ||||||
NCBI gene | 5473 | ||||||
HGNC | 9240 | ||||||
OMIM | 121010 | ||||||
RefSeq | NP_002695 | ||||||
UniProt | P02775 | ||||||
Other data | |||||||
Locus | Chr. 4 q13.3 | ||||||
|
β-Thromboglobulin (β-TG), or beta-thromboglobulin, is a chemokine protein secreted by platelets. [1] [2] It is a type of chemokine (C-X-C motif) ligand 7. [3] Along with platelet factor 4 (PF4), β-TG is one of the best-characterized platelet-specific proteins. [4] β-TG and PF4 are stored in platelet alpha granules and are released during platelet activation. [1] [4] [5] As a result, they are useful markers of platelet activation. [1] [4] β-TG also has multiple biological activities, for instance being involved in maturation of megakaryocytes. [6]
β-TG is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts. [5]
β-TG also affects megakaryocyte maturation, and thus helps in regulating platelet production. [5]
Levels of β-TG is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with PF4. [5]
β-TG levels may increase with age. [7] It is elevated in diabetes mellitus. [8]
β-TG levels have been found to be increased by treatment with the synthetic estrogen ethinylestradiol, though were not significantly increased by the natural estrogen estradiol valerate. [9] [10] [11] [12] Levels of β-TG have also been found to be increased or unchanged during normal pregnancy. [13]