Alpha granule | |
---|---|
Details | |
Part of | Platelets |
Identifiers | |
Latin | granulum alpha |
TH | H2.00.04.1.03005 |
Anatomical terminology |
Alpha granules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules that perform different functions, and include alpha granules, dense granules, and lysosomes. [1] Of these, alpha granules are the most common, [1] making up 50% to 80% of the secretory granules. [2] Alpha granules contain several growth factors. [3]
Contents include insulin-like growth factor 1, platelet-derived growth factors, TGF beta, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V, [4] and von Willebrand factor). [5]
The alpha granules express the adhesion molecule P-selectin [6] and CD63. [7] These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
A deficiency of alpha granules is known as gray platelet syndrome.
Alpha granule | |
---|---|
Details | |
Part of | Platelets |
Identifiers | |
Latin | granulum alpha |
TH | H2.00.04.1.03005 |
Anatomical terminology |
Alpha granules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules that perform different functions, and include alpha granules, dense granules, and lysosomes. [1] Of these, alpha granules are the most common, [1] making up 50% to 80% of the secretory granules. [2] Alpha granules contain several growth factors. [3]
Contents include insulin-like growth factor 1, platelet-derived growth factors, TGF beta, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V, [4] and von Willebrand factor). [5]
The alpha granules express the adhesion molecule P-selectin [6] and CD63. [7] These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
A deficiency of alpha granules is known as gray platelet syndrome.