From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
P2X purinoceptor 2 is a
protein that in humans is encoded by the P2RX2
gene .
[5]
[6]
[7]
The product of this gene belongs to the family of
purinoceptors for
ATP . This receptor functions as a cation conducting
ligand-gated ion channel . Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000187848 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000029503 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol . 56 (6): 1171–81.
doi :
10.1124/mol.56.6.1171 .
PMID
10570044 .
^ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature . 371 (6497): 519–23.
Bibcode :
1994Natur.371..519B .
doi :
10.1038/371519a0 .
PMID
7523952 .
S2CID
4371044 .
^
a
b
"Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2" .
Further reading
North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev . 82 (4): 1013–67.
doi :
10.1152/physrev.00015.2002 .
PMID
12270951 .
Barrera NP, Ormond SJ, Henderson RM, et al. (2005).
"Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize" . J. Biol. Chem . 280 (11): 10759–65.
doi :
10.1074/jbc.M412265200 .
PMID
15657042 .
Mason HS, Bourke S, Kemp PJ (2005). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species". Mol. Pharmacol . 66 (6): 1525–35.
doi :
10.1124/mol.104.000851 .
PMID
15331767 .
S2CID
24536809 .
Aschrafi A, Sadtler S, Niculescu C, et al. (2004). "Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes". J. Mol. Biol . 342 (1): 333–43.
doi :
10.1016/j.jmb.2004.06.092 .
PMID
15313628 .
Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004).
"Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels" . J. Biol. Chem . 279 (8): 6967–75.
doi :
10.1074/jbc.M307772200 .
PMID
14660627 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Järlebark LE, Housley GD, Raybould NP, et al. (2003). "ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea". NeuroReport . 13 (15): 1979–84.
doi :
10.1097/00001756-200210280-00030 .
PMID
12395104 .
S2CID
10991307 .
Khakh BS, Zhou X, Sydes J, et al. (2000).
"State-dependent cross-inhibition between transmitter-gated cation channels" (PDF) . Nature . 406 (6794): 405–10.
Bibcode :
2000Natur.406..405K .
doi :
10.1038/35019066 .
PMID
10935636 .
S2CID
4500837 .
Brändle U, Spielmanns P, Osteroth R, et al. (1997).
"Desensitization of the P2X(2) receptor controlled by alternative splicing" . FEBS Lett . 404 (2–3): 294–8.
Bibcode :
1997FEBSL.404..294B .
doi :
10.1016/S0014-5793(97)00128-2 .
PMID
9119082 .
S2CID
39951168 .
Lewis C, Neidhart S, Holy C, et al. (1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons". Nature . 377 (6548): 432–5.
Bibcode :
1995Natur.377..432L .
doi :
10.1038/377432a0 .
PMID
7566120 .
S2CID
4361850 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .