Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a
protein that in humans is encoded by the CHRNA1gene.[5] The protein encoded by this gene is a subunit of certain
nicotinic acetylcholine receptors (nAchR).
The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
Interactions
Cholinergic receptor, nicotinic, alpha 1 has been shown to
interact with
CHRND.[6][7]
Beeson D, Jeremiah S, West LF, Povey S, Newsom-Davis J (July 1990). "Assignment of the human nicotinic acetylcholine receptor genes: the alpha and delta subunit genes to chromosome 2 and the beta subunit gene to chromosome 17". Annals of Human Genetics. 54 (3): 199–208.
doi:
10.1111/j.1469-1809.1990.tb00378.x.
PMID2221824.
S2CID151624.
Schoepfer R, Luther M, Lindstrom J (January 1988). "The human medulloblastoma cell line TE671 expresses a muscle-like acetylcholine receptor. Cloning of the alpha-subunit cDNA". FEBS Letters. 226 (2): 235–40.
doi:
10.1016/0014-5793(88)81430-3.
PMID3338555.
S2CID32444215.
Oosterhuis HJ, Newsom-Davis J, Wokke JH, Molenaar PC, Weerden TV, Oen BS, Jennekens FG, Veldman H, Vincent A, Wray DW (August 1987). "The slow channel syndrome. Two new cases". Brain. 110 ( Pt 4) (4): 1061–79.
doi:
10.1093/brain/110.4.1061.
PMID3651795.
Noda M, Furutani Y, Takahashi H, Toyosato M, Tanabe T, Shimizu S, Kikyotani S, Kayano T, Hirose T, Inayama S (1983). "Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor". Nature. 305 (5937): 818–23.
Bibcode:
1983Natur.305..818N.
doi:
10.1038/305818a0.
PMID6688857.
S2CID4356354.
Vincent A, Cull-Candy SG, Newsom-Davis J, Trautmann A, Molenaar PC, Polak RL (1981). "Congenital myasthenia: end-plate acetylcholine receptors and electrophysiology in five cases". Muscle & Nerve. 4 (4): 306–18.
doi:
10.1002/mus.880040407.
PMID7254233.
S2CID31016642.
Gattenlöhner S, Brabletz T, Schultz A, Marx A, Müller-Hermelink HK, Kirchner T (1995). "Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia [correction of myastenia] gravis". Thymus. 23 (2): 103–13.
PMID7725386.
Chauplannaz G, Bady B (1995). "[Hereditary myasthenic syndromes with late onset. Value of electrophysiological tests]". Revue Neurologique. 150 (2): 142–8.
PMID7863154.
Lobos EA (September 1993). "Five subunit genes of the human muscle nicotinic acetylcholine receptor are mapped to two linkage groups on chromosomes 2 and 17". Genomics. 17 (3): 642–50.
doi:
10.1006/geno.1993.1384.
PMID7902325.
Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a
protein that in humans is encoded by the CHRNA1gene.[5] The protein encoded by this gene is a subunit of certain
nicotinic acetylcholine receptors (nAchR).
The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
Interactions
Cholinergic receptor, nicotinic, alpha 1 has been shown to
interact with
CHRND.[6][7]
Beeson D, Jeremiah S, West LF, Povey S, Newsom-Davis J (July 1990). "Assignment of the human nicotinic acetylcholine receptor genes: the alpha and delta subunit genes to chromosome 2 and the beta subunit gene to chromosome 17". Annals of Human Genetics. 54 (3): 199–208.
doi:
10.1111/j.1469-1809.1990.tb00378.x.
PMID2221824.
S2CID151624.
Schoepfer R, Luther M, Lindstrom J (January 1988). "The human medulloblastoma cell line TE671 expresses a muscle-like acetylcholine receptor. Cloning of the alpha-subunit cDNA". FEBS Letters. 226 (2): 235–40.
doi:
10.1016/0014-5793(88)81430-3.
PMID3338555.
S2CID32444215.
Oosterhuis HJ, Newsom-Davis J, Wokke JH, Molenaar PC, Weerden TV, Oen BS, Jennekens FG, Veldman H, Vincent A, Wray DW (August 1987). "The slow channel syndrome. Two new cases". Brain. 110 ( Pt 4) (4): 1061–79.
doi:
10.1093/brain/110.4.1061.
PMID3651795.
Noda M, Furutani Y, Takahashi H, Toyosato M, Tanabe T, Shimizu S, Kikyotani S, Kayano T, Hirose T, Inayama S (1983). "Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor". Nature. 305 (5937): 818–23.
Bibcode:
1983Natur.305..818N.
doi:
10.1038/305818a0.
PMID6688857.
S2CID4356354.
Vincent A, Cull-Candy SG, Newsom-Davis J, Trautmann A, Molenaar PC, Polak RL (1981). "Congenital myasthenia: end-plate acetylcholine receptors and electrophysiology in five cases". Muscle & Nerve. 4 (4): 306–18.
doi:
10.1002/mus.880040407.
PMID7254233.
S2CID31016642.
Gattenlöhner S, Brabletz T, Schultz A, Marx A, Müller-Hermelink HK, Kirchner T (1995). "Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia [correction of myastenia] gravis". Thymus. 23 (2): 103–13.
PMID7725386.
Chauplannaz G, Bady B (1995). "[Hereditary myasthenic syndromes with late onset. Value of electrophysiological tests]". Revue Neurologique. 150 (2): 142–8.
PMID7863154.
Lobos EA (September 1993). "Five subunit genes of the human muscle nicotinic acetylcholine receptor are mapped to two linkage groups on chromosomes 2 and 17". Genomics. 17 (3): 642–50.
doi:
10.1006/geno.1993.1384.
PMID7902325.