Glutamate [NMDA] receptor subunit zeta-1 is a
protein that in humans is encoded by the GRIN1gene.[5][6]
The protein encoded by this gene is a critical subunit of
N-methyl-D-aspartate receptors, members of the
glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a
ligand-gated ion channel. These subunits play a key role in the
plasticity of
synapses, which is believed to underlie memory and learning. The gene consists of 21
exons and is alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing demonstrated in human, mouse and rat.[7][8][9][10] Cell-specific factors are thought to control expression of different
isoforms, possibly contributing to the functional diversity of the subunits.[6]
Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–688.
PMID9745929.
Adriani W, Felici A, Sargolini F, Roullet P, Usiello A, Oliverio A, Mele A (November 1998). "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". Experimental Brain Research. 123 (1–2): 52–59.
doi:
10.1007/s002210050544.
PMID9835392.
S2CID8388670.
Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999). "The glutamate receptor ion channels". Pharmacological Reviews. 51 (1): 7–61.
PMID10049997.
Zimmer M, Fink TM, Franke Y, Lichter P, Spiess J (July 1995). "Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)". Gene. 159 (2): 219–223.
doi:
10.1016/0378-1119(95)00044-7.
PMID7622053.
Foldes RL, Rampersad V, Kamboj RK (September 1993). "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing". Gene. 131 (2): 293–298.
doi:
10.1016/0378-1119(93)90309-Q.
PMID8406025.
Collins C, Duff C, Duncan AM, Planells-Cases R, Sun W, Norremolle A, et al. (July 1993). "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively". Genomics. 17 (1): 237–239.
doi:
10.1006/geno.1993.1311.
PMID8406459.
Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (November 1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". The European Journal of Neuroscience. 7 (11): 2285–2293.
doi:
10.1111/j.1460-9568.1995.tb00649.x.
PMID8563977.
S2CID27201873.
Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (September 1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–321.
doi:
10.1016/1055-8330(95)90021-7.
PMID8581564.
Glutamate [NMDA] receptor subunit zeta-1 is a
protein that in humans is encoded by the GRIN1gene.[5][6]
The protein encoded by this gene is a critical subunit of
N-methyl-D-aspartate receptors, members of the
glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a
ligand-gated ion channel. These subunits play a key role in the
plasticity of
synapses, which is believed to underlie memory and learning. The gene consists of 21
exons and is alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing demonstrated in human, mouse and rat.[7][8][9][10] Cell-specific factors are thought to control expression of different
isoforms, possibly contributing to the functional diversity of the subunits.[6]
Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–688.
PMID9745929.
Adriani W, Felici A, Sargolini F, Roullet P, Usiello A, Oliverio A, Mele A (November 1998). "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". Experimental Brain Research. 123 (1–2): 52–59.
doi:
10.1007/s002210050544.
PMID9835392.
S2CID8388670.
Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999). "The glutamate receptor ion channels". Pharmacological Reviews. 51 (1): 7–61.
PMID10049997.
Zimmer M, Fink TM, Franke Y, Lichter P, Spiess J (July 1995). "Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)". Gene. 159 (2): 219–223.
doi:
10.1016/0378-1119(95)00044-7.
PMID7622053.
Foldes RL, Rampersad V, Kamboj RK (September 1993). "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing". Gene. 131 (2): 293–298.
doi:
10.1016/0378-1119(93)90309-Q.
PMID8406025.
Collins C, Duff C, Duncan AM, Planells-Cases R, Sun W, Norremolle A, et al. (July 1993). "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively". Genomics. 17 (1): 237–239.
doi:
10.1006/geno.1993.1311.
PMID8406459.
Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (November 1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". The European Journal of Neuroscience. 7 (11): 2285–2293.
doi:
10.1111/j.1460-9568.1995.tb00649.x.
PMID8563977.
S2CID27201873.
Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (September 1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–321.
doi:
10.1016/1055-8330(95)90021-7.
PMID8581564.
