Glutamate receptor, ionotropic kainate 5 is a
protein that in humans is encoded by the GRIK5gene.[5][6]
Function
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory
neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[6]
Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia". Brain Res. 751 (2): 217–31.
doi:
10.1016/S0006-8993(96)01404-7.
PMID9099808.
S2CID9796632.
Kamm C, Leung J, Joseph S, et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene". Mov. Disord. 19 (7): 845–7.
doi:
10.1002/mds.20095.
PMID15254951.
S2CID20276163.
Glutamate receptor, ionotropic kainate 5 is a
protein that in humans is encoded by the GRIK5gene.[5][6]
Function
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory
neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[6]
Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia". Brain Res. 751 (2): 217–31.
doi:
10.1016/S0006-8993(96)01404-7.
PMID9099808.
S2CID9796632.
Kamm C, Leung J, Joseph S, et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene". Mov. Disord. 19 (7): 845–7.
doi:
10.1002/mds.20095.
PMID15254951.
S2CID20276163.