From Wikipedia, the free encyclopedia
CHRNA2
Identifiers
Aliases CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
External IDs OMIM: 118502; MGI: 87886; HomoloGene: 20193; GeneCards: CHRNA2; OMA: CHRNA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144803

RefSeq (protein)

NP_659052

Location (UCSC) Chr 8: 27.46 – 27.48 Mb Chr 14: 66.37 – 66.39 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. [5] [6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Knockout of this gene in mice potentiates nicotine-modulated behaviors. [7] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. [8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120903Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022041Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi: 10.1016/0888-7543(92)90008-G. PMID  1505988.
  6. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
  7. ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi: 10.1523/JNEUROSCI.4731-12.2013. PMC  3831006. PMID  23637165.
  8. ^ Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (May 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi: 10.1101/lm.045369.117. PMC  5435881. PMID  28507032.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


From Wikipedia, the free encyclopedia
CHRNA2
Identifiers
Aliases CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
External IDs OMIM: 118502; MGI: 87886; HomoloGene: 20193; GeneCards: CHRNA2; OMA: CHRNA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144803

RefSeq (protein)

NP_659052

Location (UCSC) Chr 8: 27.46 – 27.48 Mb Chr 14: 66.37 – 66.39 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. [5] [6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Knockout of this gene in mice potentiates nicotine-modulated behaviors. [7] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. [8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120903Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022041Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi: 10.1016/0888-7543(92)90008-G. PMID  1505988.
  6. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
  7. ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi: 10.1523/JNEUROSCI.4731-12.2013. PMC  3831006. PMID  23637165.
  8. ^ Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (May 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi: 10.1101/lm.045369.117. PMC  5435881. PMID  28507032.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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