Glutamate [NMDA] receptor subunit epsilon-3 is a
protein that in humans is encoded by the GRIN2Cgene.[5][6]
Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (
GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (
GRIN2A), NMDAR2B (
GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (
GRIN2D).[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5.
doi:
10.1006/geno.1997.5132.
PMID9480759.
Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40.
Bibcode:
1995Sci...269.1737K.
doi:
10.1126/science.7569905.
PMID7569905.
Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80.
doi:
10.1002/ana.410370314.
PMID7695237.
S2CID24405132.
Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, Kobayashi H, Mishina M, Tsuji S (1993). "Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel". Biochem. Biophys. Res. Commun. 197 (2): 922–6.
doi:
10.1006/bbrc.1993.2567.
PMID8267632.
Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93.
doi:
10.1111/j.1460-9568.1995.tb00649.x.
PMID8563977.
S2CID27201873.
Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21.
doi:
10.1016/1055-8330(95)90021-7.
PMID8581564.
Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8.
doi:
10.1097/00002030-199605000-00003.
PMID8724036.
S2CID1669986.
Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7.
doi:
10.1016/0006-8993(95)01197-8.
PMID8822372.
S2CID44260060.
Dreyer EB, Lipton SA (1995). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7.
doi:
10.1111/j.1460-9568.1995.tb01048.x.
PMID8845955.
S2CID7370984.
Lin YJ, Bovetto S, Carver JM, Giordano T (1996). "Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery". Brain Res. Mol. Brain Res. 43 (1–2): 57–64.
doi:
10.1016/S0169-328X(96)00146-5.
PMID9037519.
Kurschner C, Mermelstein PG, Holden WT,
Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72.
doi:
10.1006/mcne.1998.0679.
PMID9647694.
S2CID36534759.
Glutamate [NMDA] receptor subunit epsilon-3 is a
protein that in humans is encoded by the GRIN2Cgene.[5][6]
Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (
GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (
GRIN2A), NMDAR2B (
GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (
GRIN2D).[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5.
doi:
10.1006/geno.1997.5132.
PMID9480759.
Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40.
Bibcode:
1995Sci...269.1737K.
doi:
10.1126/science.7569905.
PMID7569905.
Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80.
doi:
10.1002/ana.410370314.
PMID7695237.
S2CID24405132.
Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, Kobayashi H, Mishina M, Tsuji S (1993). "Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel". Biochem. Biophys. Res. Commun. 197 (2): 922–6.
doi:
10.1006/bbrc.1993.2567.
PMID8267632.
Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93.
doi:
10.1111/j.1460-9568.1995.tb00649.x.
PMID8563977.
S2CID27201873.
Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21.
doi:
10.1016/1055-8330(95)90021-7.
PMID8581564.
Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8.
doi:
10.1097/00002030-199605000-00003.
PMID8724036.
S2CID1669986.
Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7.
doi:
10.1016/0006-8993(95)01197-8.
PMID8822372.
S2CID44260060.
Dreyer EB, Lipton SA (1995). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7.
doi:
10.1111/j.1460-9568.1995.tb01048.x.
PMID8845955.
S2CID7370984.
Lin YJ, Bovetto S, Carver JM, Giordano T (1996). "Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery". Brain Res. Mol. Brain Res. 43 (1–2): 57–64.
doi:
10.1016/S0169-328X(96)00146-5.
PMID9037519.
Kurschner C, Mermelstein PG, Holden WT,
Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72.
doi:
10.1006/mcne.1998.0679.
PMID9647694.
S2CID36534759.