LIGHT stands for "homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes". In the
cluster of differentiation terminology it is classified as CD258.
Function
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). Two alternatively spliced transcript variant encoding distinct isoforms have been reported.[6]
This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells,[8] trigger apoptosis of various tumor cells[9] and play a role in vascular normalisation processes.[10] This protein is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes.[11]
Similar to how
CD4 is the primary mediating receptor in HIV infection, the
HSV glycoprotein (
gD) binds to the
HVEM receptor which is demanded by TNFSF14/LIGHT lowering the ability for LIGHT to activate the
NFκB pathway. NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting
caspase 8. When gD from HSV binds to HVEM, LIGHT is non-competitively inhibited from binding, encouraging apoptosis in the infected cell.[7]
^
abWare C (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp.
776–801.
ISBN978-0-7817-6519-0.
Yang D, Zhai Y, Zhang M (2003). "LIGHT, a new member of the TNF superfamily". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 206–10.
PMID12456019.
LIGHT stands for "homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes". In the
cluster of differentiation terminology it is classified as CD258.
Function
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). Two alternatively spliced transcript variant encoding distinct isoforms have been reported.[6]
This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells,[8] trigger apoptosis of various tumor cells[9] and play a role in vascular normalisation processes.[10] This protein is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes.[11]
Similar to how
CD4 is the primary mediating receptor in HIV infection, the
HSV glycoprotein (
gD) binds to the
HVEM receptor which is demanded by TNFSF14/LIGHT lowering the ability for LIGHT to activate the
NFκB pathway. NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting
caspase 8. When gD from HSV binds to HVEM, LIGHT is non-competitively inhibited from binding, encouraging apoptosis in the infected cell.[7]
^
abWare C (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp.
776–801.
ISBN978-0-7817-6519-0.
Yang D, Zhai Y, Zhang M (2003). "LIGHT, a new member of the TNF superfamily". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 206–10.
PMID12456019.