From Wikipedia, the free encyclopedia
(Redirected from EMR4)
egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
SymbolEMR1
Alt. symbolsTM7LN3
IUPHAR 182
NCBI gene 2015
HGNC 3336
OMIM 600493
RefSeq NM_001974
UniProt Q14246
Other data
Locus Chr. 19 p13.3
Search for
Structures Swiss-model
Domains InterPro
egf-like module containing, mucin-like, hormone receptor-like 2
Identifiers
SymbolEMR2
IUPHAR 183
NCBI gene 30817
HGNC 3337
OMIM 606100
RefSeq NM_152916
UniProt Q9UHX3
Other data
Locus Chr. 19 p13.1
Search for
Structures Swiss-model
Domains InterPro
egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
SymbolEMR3
IUPHAR 184
NCBI gene 84658
HGNC 23647
OMIM 606101
RefSeq NM_032571
UniProt Q9BY15
Other data
Locus Chr. 19 p13.1
Search for
Structures Swiss-model
Domains InterPro
egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
Identifiers
SymbolEMR4P
Alt. symbolsGPR127
NCBI gene 326342
HGNC 19240
RefSeq XM_940358
UniProt Q86SQ3
Other data
Locus Chr. 19 p13.3
Search for
Structures Swiss-model
Domains InterPro

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. [1] [2] [3] [4] There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55. [5]

References

  1. ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi: 10.1016/0888-7543(95)80218-B. PMID  7601460.
  2. ^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi: 10.1006/geno.2000.6238. PMID  10903844.
  3. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J. Biol. Chem. 276 (22): 18863–70. doi: 10.1074/jbc.M101147200. PMID  11279179.
  4. ^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD (2006). "Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE". DNA Seq. 17 (1): 8–14. doi: 10.1080/10425170500355737. PMID  16753812. S2CID  11216477.
  5. ^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J (2004). "The EGF-TM7 family: a postgenomic view". Immunogenetics. 55 (10): 655–66. doi: 10.1007/s00251-003-0625-2. PMID  14647991. S2CID  28689160.

External links


From Wikipedia, the free encyclopedia
(Redirected from EMR4)
egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
SymbolEMR1
Alt. symbolsTM7LN3
IUPHAR 182
NCBI gene 2015
HGNC 3336
OMIM 600493
RefSeq NM_001974
UniProt Q14246
Other data
Locus Chr. 19 p13.3
Search for
Structures Swiss-model
Domains InterPro
egf-like module containing, mucin-like, hormone receptor-like 2
Identifiers
SymbolEMR2
IUPHAR 183
NCBI gene 30817
HGNC 3337
OMIM 606100
RefSeq NM_152916
UniProt Q9UHX3
Other data
Locus Chr. 19 p13.1
Search for
Structures Swiss-model
Domains InterPro
egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
SymbolEMR3
IUPHAR 184
NCBI gene 84658
HGNC 23647
OMIM 606101
RefSeq NM_032571
UniProt Q9BY15
Other data
Locus Chr. 19 p13.1
Search for
Structures Swiss-model
Domains InterPro
egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
Identifiers
SymbolEMR4P
Alt. symbolsGPR127
NCBI gene 326342
HGNC 19240
RefSeq XM_940358
UniProt Q86SQ3
Other data
Locus Chr. 19 p13.3
Search for
Structures Swiss-model
Domains InterPro

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. [1] [2] [3] [4] There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55. [5]

References

  1. ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi: 10.1016/0888-7543(95)80218-B. PMID  7601460.
  2. ^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi: 10.1006/geno.2000.6238. PMID  10903844.
  3. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J. Biol. Chem. 276 (22): 18863–70. doi: 10.1074/jbc.M101147200. PMID  11279179.
  4. ^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD (2006). "Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE". DNA Seq. 17 (1): 8–14. doi: 10.1080/10425170500355737. PMID  16753812. S2CID  11216477.
  5. ^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J (2004). "The EGF-TM7 family: a postgenomic view". Immunogenetics. 55 (10): 655–66. doi: 10.1007/s00251-003-0625-2. PMID  14647991. S2CID  28689160.

External links



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