alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6
gene.
Function
ABHD6 is a serine hydrolyzing enzyme that possesses typical
α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of
tumours.[5]
ABHD6 accounts for about 4% of 2-AG brain
hydrolysis.[7] Together,
monoacylglycerol lipase (MAGL),
ABHD12, and ABHD6 control about 99% of 2-AG signalling in the brain,[7][8] and each enzyme exhibits a distinct
subcellular distribution, suggesting that they regulate distinct pools of 2-AG in the
nervous system.[9]
alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6
gene.
Function
ABHD6 is a serine hydrolyzing enzyme that possesses typical
α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of
tumours.[5]
ABHD6 accounts for about 4% of 2-AG brain
hydrolysis.[7] Together,
monoacylglycerol lipase (MAGL),
ABHD12, and ABHD6 control about 99% of 2-AG signalling in the brain,[7][8] and each enzyme exhibits a distinct
subcellular distribution, suggesting that they regulate distinct pools of 2-AG in the
nervous system.[9]