A phospholipase is an enzyme that hydrolyzes phospholipids [1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze:
- Phospholipase A
- Phospholipase A1 – cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering).
- Phospholipase A2 – cleaves the sn-2 acyl chain, releasing arachidonic acid.
- Phospholipase B – cleaves both sn-1 and sn-2 acyl chains; this enzyme is also known as a lysophospholipase.
- Phospholipase C – cleaves before the phosphate, releasing diacylglycerol and a phosphate-containing head group. PLCs play a central role in signal transduction, releasing the second messenger inositol triphosphate.
- Phospholipase D – cleaves after the phosphate, releasing phosphatidic acid and an alcohol.
Types C and D are considered phosphodiesterases.
Endothelial lipase is primarily a phospholipase. [2]
Phospholipase A2 acts on the intact lecithin molecule and hydrolyzes the fatty acid esterified to the second carbon atom. The resulting products are lysolecithin and a fatty acid. Phospholipase A2 is an enzyme present in the venom of bees, blennies and viper snakes. [3]
- ^ "phospholipase" at Dorland's Medical Dictionary
- ^ Yu JE, Han SY, Wolfson B, Zhou Q (2018). "The role of endothelial lipase in lipid metabolism, inflammation, and cancer". Histology and Histopathology. 33 (1): 1–10. doi: 10.14670/HH-11-905. PMC 5858721. PMID 28540715.
- ^ D. M. Vasudevan & S. Sreekumari, Textbook of Biochemistry (5th ed.)
- Tappia, Paramjit S. & Dhalla, Naranjan S. (Editors): Phospholipases in Health and Disease. Springer, 2014. ISBN 978-1-4939-0463-1 [Print]; ISBN 978-1-4939-0464-8 [eBook]
- Phospholipases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This enzyme-related article is a stub. You can help Wikipedia by expanding it. |
A phospholipase is an enzyme that hydrolyzes phospholipids [1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze:
- Phospholipase A
- Phospholipase A1 – cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering).
- Phospholipase A2 – cleaves the sn-2 acyl chain, releasing arachidonic acid.
- Phospholipase B – cleaves both sn-1 and sn-2 acyl chains; this enzyme is also known as a lysophospholipase.
- Phospholipase C – cleaves before the phosphate, releasing diacylglycerol and a phosphate-containing head group. PLCs play a central role in signal transduction, releasing the second messenger inositol triphosphate.
- Phospholipase D – cleaves after the phosphate, releasing phosphatidic acid and an alcohol.
Types C and D are considered phosphodiesterases.
Endothelial lipase is primarily a phospholipase. [2]
Phospholipase A2 acts on the intact lecithin molecule and hydrolyzes the fatty acid esterified to the second carbon atom. The resulting products are lysolecithin and a fatty acid. Phospholipase A2 is an enzyme present in the venom of bees, blennies and viper snakes. [3]
- ^ "phospholipase" at Dorland's Medical Dictionary
- ^ Yu JE, Han SY, Wolfson B, Zhou Q (2018). "The role of endothelial lipase in lipid metabolism, inflammation, and cancer". Histology and Histopathology. 33 (1): 1–10. doi: 10.14670/HH-11-905. PMC 5858721. PMID 28540715.
- ^ D. M. Vasudevan & S. Sreekumari, Textbook of Biochemistry (5th ed.)
- Tappia, Paramjit S. & Dhalla, Naranjan S. (Editors): Phospholipases in Health and Disease. Springer, 2014. ISBN 978-1-4939-0463-1 [Print]; ISBN 978-1-4939-0464-8 [eBook]
- Phospholipases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
|
| This enzyme-related article is a stub. You can help Wikipedia by expanding it. |