Solute carrier organic anion transporter family member 1B1 is a
protein that in humans is encoded by the SLCO1B1gene.[5][6]Pharmacogenomic research indicates that genetic variations in this gene are associated with response to
simvastatin.[7] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using
genotyping or whole
exomesequencing.[8]
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60.
doi:
10.1006/bbrc.2000.2922.
PMID10873595.
Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13.
doi:
10.1124/jpet.302.2.804.
PMID12130747.
Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65.
doi:
10.1016/S0009-9236(03)00060-2.
PMID12811365.
S2CID6570648.
Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics. 14 (7): 429–40.
doi:
10.1097/01.fpc.0000114750.08559.32.
PMID15226675.
Solute carrier organic anion transporter family member 1B1 is a
protein that in humans is encoded by the SLCO1B1gene.[5][6]Pharmacogenomic research indicates that genetic variations in this gene are associated with response to
simvastatin.[7] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using
genotyping or whole
exomesequencing.[8]
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60.
doi:
10.1006/bbrc.2000.2922.
PMID10873595.
Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13.
doi:
10.1124/jpet.302.2.804.
PMID12130747.
Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65.
doi:
10.1016/S0009-9236(03)00060-2.
PMID12811365.
S2CID6570648.
Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics. 14 (7): 429–40.
doi:
10.1097/01.fpc.0000114750.08559.32.
PMID15226675.