SLC7A3 (GENE)

SLC7A3
Identifiers
Aliases	SLC7A3, ATRC3, CAT-3, CAT3, solute carrier family 7 member 3
External IDs	OMIM: 300443; MGI: 1100521; HomoloGene: 56382; GeneCards: SLC7A3; OMA: SLC7A3 - orthologs
Gene location ( Human)
Chr.	X chromosome (human)
End	70,931,125 bp
Gene location ( Mouse)
Chr.	X chromosome (mouse)
End	100,129,626 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; gonad; ; tibialis anterior muscle; ; ventricular zone; ; thymus; ; ganglionic eminence; ; testicle; ; gastric mucosa; ; mucosa of ileum; ; body of uterus;
	Top expressed in
	epiblast; ; embryo; ; dorsomedial hypothalamic nucleus; ; otic placode; ; ventral tegmental area; ; paraventricular nucleus of hypothalamus; ; central gray substance of midbrain; ; lateral hypothalamus; ; primitive streak; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	basic amino acid transmembrane transporter activity; L-lysine transmembrane transporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity; L-ornithine transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	basic amino acid transmembrane transport; L-lysine transmembrane transport; L-alpha-amino acid transmembrane transport; L-arginine transmembrane transport; amino acid transport; transmembrane transport; L-arginine import across plasma membrane; L-ornithine transmembrane transport;
	Sources: Amigo / QuickGO
Orthologs
	84889
	11989
	ENSG00000165349
	ENSMUSG00000031297
	Q8WY07
	P70423
	NM_032803; NM_001048164
	NM_001301840; NM_007515
	NP_001041629; NP_116192
	NP_001288769; NP_031541
	Wikidata
View/Edit Human	View/Edit Mouse

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.^[5]^[6]

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165349 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031297 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues". Biochemistry. 40 (41): 12387–94. doi: 10.1021/bi011345c. PMID 11591158.
^ ^a ^b "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3".

Hosokawa H, Sawamura T, Kobayashi S, et al. (1997). "Cloning and characterization of a brain-specific cationic amino acid transporter". J. Biol. Chem. 272 (13): 8717–22. doi: 10.1074/jbc.272.13.8717. PMID 9079705.
Ito K, Groudine M (1997). "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain". J. Biol. Chem. 272 (42): 26780–6. doi: 10.1074/jbc.272.42.26780. PMID 9334265.
Hosokawa H, Ninomiya H, Sawamura T, et al. (1999). "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain". Brain Res. 838 (1–2): 158–65. doi: 10.1016/S0006-8993(99)01686-8. PMID 10446328. S2CID 33405664.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gilles W, Vulcu SD, Liewald JF, et al. (2005). "Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3". Biochim. Biophys. Acta. 1668 (2): 234–9. doi: 10.1016/j.bbamem.2004.12.011. PMID 15737334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117. PMID 16303743.
Rotmann A, Vékony N, Gassner D, et al. (2006). "Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane". Biochem. J. 395 (1): 117–23. doi: 10.1042/BJ20051558. PMC 1409692. PMID 16332251.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165349 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031297 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11591158-5] Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues". Biochemistry. 40 (41): 12387–94. doi: 10.1021/bi011345c. PMID 11591158.

[entrez-6] "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3".

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