From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Sodium/myo-inositol cotransporter is a
protein that in humans is encoded by the SLC5A3
gene .
[5]
[6]
Expression of the myo-inositol transport protein is regulated by
osmotic stress .
[7]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000198743 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000089774 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB (Jul 1995).
"The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21" . Genomics . 25 (2): 507–13.
doi :
10.1016/0888-7543(95)80052-N .
PMID
7789985 .
^
"Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3" .
^ Lee SD, Choi SY, Lim SW, Lamitina ST, Ho SN, Go WY, Kwon HM (2011).
"TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways" . AJP: Renal Physiology . 300 (3): F707–F715.
doi :
10.1152/ajprenal.00227.2010 .
PMC
3064130 .
PMID
21209002 .
Further reading
Kwon HM, Yamauchi A, Uchida S, et al. (1992).
"Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein" . J. Biol. Chem . 267 (9): 6297–301.
doi :
10.1016/S0021-9258(18)42695-6 .
PMID
1372904 .
Berry GT, Mallee JJ, Blouin JL, Antonarakis SE (1996). "The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene". Cytogenet. Cell Genet . 73 (1–2): 77–8.
doi :
10.1159/000134311 .
PMID
8646889 .
Mallee JJ, Atta MG, Lorica V, et al. (1998).
"The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter" . Genomics . 46 (3): 459–65.
doi :
10.1006/geno.1997.5055 .
PMID
9441750 .
Porcellati F, Hlaing T, Togawa M, et al. (1998). "Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts". Am. J. Physiol . 274 (5 Pt 1): C1215–25.
doi :
10.1152/ajpcell.1998.274.5.C1215 .
PMID
9612208 .
S2CID
22626824 .
Rim JS, Atta MG, Dahl SC, et al. (1998).
"Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region" . J. Biol. Chem . 273 (32): 20615–21.
doi :
10.1074/jbc.273.32.20615 .
PMC
2365891 .
PMID
9685419 .
Hattori M, Fujiyama A, Taylor TD, et al. (2000).
"The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9.
Bibcode :
2000Natur.405..311H .
doi :
10.1038/35012518 .
PMID
10830953 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Suzuki Y, Yamashita R, Shirota M, et al. (2004).
"Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions" . Genome Res . 14 (9): 1711–8.
doi :
10.1101/gr.2435604 .
PMC
515316 .
PMID
15342556 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Thangaraju M, Gopal E, Martin PM, et al. (2007).
"SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases" . Cancer Res . 66 (24): 11560–4.
doi :
10.1158/0008-5472.CAN-06-1950 .
PMID
17178845 .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):