Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a
membrane transport protein that in humans is encoded by the SLC4A4gene.[5][6][7]
Function
Sodium bicarbonate
cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate
co-transport is involved in bicarbonate secretion/absorption and
intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM][7]
Choi I, Romero MF, Khandoudi N, et al. (1999). "Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)". Am. J. Physiol. 276 (3 Pt 1): C576–84.
doi:
10.1152/ajpcell.1999.276.3.C576.
PMID10069984.
S2CID23345395.
Igarashi T, Inatomi J, Sekine T, et al. (1999). "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities". Nat. Genet. 23 (3): 264–6.
doi:
10.1038/15440.
PMID10545938.
S2CID547845.
Park K, Hurley PT, Roussa E, et al. (2002). "Expression of a sodium bicarbonate cotransporter in human parotid salivary glands". Arch. Oral Biol. 47 (1): 1–9.
doi:
10.1016/S0003-9969(01)00098-X.
PMID11743927.
Tatishchev S, Abuladze N, Pushkin A, et al. (2003). "Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation". Biochemistry. 42 (3): 755–65.
doi:
10.1021/bi026826q.
PMID12534288.
Yamada H, Yamazaki S, Moriyama N, et al. (2003). "Localization of NBC-1 variants in human kidney and renal cell carcinoma". Biochem. Biophys. Res. Commun. 310 (4): 1213–8.
doi:
10.1016/j.bbrc.2003.09.147.
PMID14559244.
Alvarez BV, Loiselle FB, Supuran CT, et al. (2003). "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter". Biochemistry. 42 (42): 12321–9.
doi:
10.1021/bi0353124.
PMID14567693.
Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a
membrane transport protein that in humans is encoded by the SLC4A4gene.[5][6][7]
Function
Sodium bicarbonate
cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate
co-transport is involved in bicarbonate secretion/absorption and
intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM][7]
Choi I, Romero MF, Khandoudi N, et al. (1999). "Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)". Am. J. Physiol. 276 (3 Pt 1): C576–84.
doi:
10.1152/ajpcell.1999.276.3.C576.
PMID10069984.
S2CID23345395.
Igarashi T, Inatomi J, Sekine T, et al. (1999). "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities". Nat. Genet. 23 (3): 264–6.
doi:
10.1038/15440.
PMID10545938.
S2CID547845.
Park K, Hurley PT, Roussa E, et al. (2002). "Expression of a sodium bicarbonate cotransporter in human parotid salivary glands". Arch. Oral Biol. 47 (1): 1–9.
doi:
10.1016/S0003-9969(01)00098-X.
PMID11743927.
Tatishchev S, Abuladze N, Pushkin A, et al. (2003). "Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation". Biochemistry. 42 (3): 755–65.
doi:
10.1021/bi026826q.
PMID12534288.
Yamada H, Yamazaki S, Moriyama N, et al. (2003). "Localization of NBC-1 variants in human kidney and renal cell carcinoma". Biochem. Biophys. Res. Commun. 310 (4): 1213–8.
doi:
10.1016/j.bbrc.2003.09.147.
PMID14559244.
Alvarez BV, Loiselle FB, Supuran CT, et al. (2003). "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter". Biochemistry. 42 (42): 12321–9.
doi:
10.1021/bi0353124.
PMID14567693.