SLC2A6 (GENE)

SLC2A6
Identifiers
Aliases	SLC2A6, GLUT6, GLUT9, HSA011372, solute carrier family 2 member 6
External IDs	OMIM: 606813; MGI: 2443286; HomoloGene: 69236; GeneCards: SLC2A6; OMA: SLC2A6 - orthologs
Gene location ( Human)
Chr.	Chromosome 9 (human)
End	133,479,127 bp
Gene location ( Mouse)
Chr.	Chromosome 2 (mouse)
End	26,918,010 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; prefrontal cortex; ; right frontal lobe; ; primary visual cortex; ; Brodmann area 9; ; blood; ; superior frontal gyrus; ; anterior cingulate cortex; ; hypothalamus;
	Top expressed in
	granulocyte; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; facial motor nucleus; ; blood; ; cerebellar cortex; ; morula; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glucose transmembrane transporter activity; carbohydrate:proton symporter activity; transmembrane transporter activity; transporter activity; D-glucose transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	carbohydrate transport; glucose import; transmembrane transport; hexose transmembrane transport; proton transmembrane transport; glucose transmembrane transport;
	Sources: Amigo / QuickGO
Orthologs
	11182
	227659
	ENSG00000160326; ENSG00000281165
	ENSMUSG00000036067
	Q9UGQ3
	Q3UDF0
	NM_001145099; NM_017585
	NM_001177627; NM_172659
	NP_001138571; NP_060055
	NP_001171098; NP_766247
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.^[5]^[6]

Function

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM]^[6]

References

^ ^a ^b ^c ENSG00000281165 GRCh38: Ensembl release 89: ENSG00000160326, ENSG00000281165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036067 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Doege H, Bocianski A, Joost HG, Schürmann A (September 2000). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes". The Biochemical Journal. 350 Pt 3 (Pt 3): 771–6. doi: 10.1042/0264-6021:3500771. PMC 1221309. PMID 10970791.
^ ^a ^b "Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6".

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi: 10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi: 10.1016/S0378-1119(97)00411-3. PMID 9373149.
Richardson S, Neama G, Phillips T, Bell S, Carter SD, Moley KH, Moley JF, Vannucci SJ, Mobasheri A (February 2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthritis and Cartilage. 11 (2): 92–101. doi: 10.1053/joca.2002.0858. PMID 12554125.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117. PMID 16303743.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] ENSG00000281165 GRCh38: Ensembl release 89: ENSG00000160326, ENSG00000281165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036067 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10970791-5] Doege H, Bocianski A, Joost HG, Schürmann A (September 2000). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes". The Biochemical Journal. 350 Pt 3 (Pt 3): 771–6. doi: 10.1042/0264-6021:3500771. PMC 1221309. PMID 10970791.

[entrez-6] "Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6".

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Function

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Function

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