PROTON-COUPLED AMINO ACID TRANSPORTER 1

SLC36A1
Identifiers
Aliases	SLC36A1, Dct1, LYAAT1, PAT1, TRAMD3, solute carrier family 36 member 1
External IDs	OMIM: 606561; MGI: 2445299; HomoloGene: 121860; GeneCards: SLC36A1; OMA: SLC36A1 - orthologs
Gene location ( Human)
Chr.	Chromosome 5 (human)
End	151,492,379 bp
Gene location ( Mouse)
Chr.	Chromosome 11 (mouse)
End	55,127,156 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; right hemisphere of cerebellum; ; mucosa of ileum; ; trabecular bone; ; trigeminal ganglion; ; mucosa of colon; ; rectum; ; tendon of biceps brachii; ; mucosa of sigmoid colon;
	Top expressed in
	superior cervical ganglion; ; spinal ganglia; ; lumbar spinal ganglion; ; visual cortex; ; left colon; ; jejunum; ; stroma of bone marrow; ; yolk sac; ; primary visual cortex; ; islet of Langerhans;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	amino acid:proton symporter activity; L-proline transmembrane transporter activity; neutral amino acid transmembrane transporter activity; proton transmembrane transporter activity; L-alanine transmembrane transporter activity; glycine transmembrane transporter activity; symporter activity; amino acid transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; lysosomal membrane; endoplasmic reticulum; lysosome;
Biological process	L-alanine transport; proton transmembrane transport; proline transmembrane transport; ion transport; proline transport; amino acid transport; glycine transport; neutral amino acid transport; transmembrane transport; amino acid transmembrane transport; transport;
	Sources: Amigo / QuickGO
Orthologs
	206358
	215335
	ENSG00000123643
	ENSMUSG00000020261
	Q7Z2H8
	Q8K4D3
	NM_001308150; NM_001308151; NM_078483; NM_001349740
	NM_153139
	NP_001295079; NP_001295080; NP_510968; NP_001336669
	NP_694779
	Wikidata
View/Edit Human	View/Edit Mouse

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.^[5]^[6]^[7]

This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123643 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020261 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem. 277 (25): 22966–73. doi: 10.1074/jbc.M200374200. PMID 11959859.
^ Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A. 98 (13): 7206–11. Bibcode: 2001PNAS...98.7206S. doi: 10.1073/pnas.121183498. PMC 34647. PMID 11390972.
^ ^a ^b "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi: 10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi: 10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi: 10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Chen Z, Fei YJ, Anderson CM, et al. (2003). "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2". J. Physiol. 546 (Pt 2): 349–61. doi: 10.1113/jphysiol.2002.026500. PMC 2342508. PMID 12527723.
Wreden CC, Johnson J, Tran C, et al. (2003). "The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons". J. Neurosci. 23 (4): 1265–75. doi: 10.1523/JNEUROSCI.23-04-01265.2003. PMC 6742289. PMID 12598615.
Boll M, Foltz M, Rubio-Aliaga I, Daniel H (2004). "A cluster of proton/amino acid transporter genes in the human and mouse genomes". Genomics. 82 (1): 47–56. doi: 10.1016/S0888-7543(03)00099-5. PMID 12809675.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Bermingham JR, Pennington J (2004). "Organization and expression of the SLC36 cluster of amino acid transporter genes". Mamm. Genome. 15 (2): 114–25. doi: 10.1007/s00335-003-2319-3. PMID 15058382. S2CID 21418124.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi: 10.1101/gr.2576704. PMC 528930. PMID 15489336.
Anderson CM, Grenade DS, Boll M, et al. (2004). "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat". Gastroenterology. 127 (5): 1410–22. doi: 10.1053/j.gastro.2004.08.017. PMID 15521011.
Anderson CM, Thwaites DT (2005). "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)". J. Cell. Physiol. 204 (2): 604–13. doi: 10.1002/jcp.20337. PMID 15754324. S2CID 31443973.
Abbot EL, Grenade DS, Kennedy DJ, et al. (2006). "Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1". Br. J. Pharmacol. 147 (3): 298–306. doi: 10.1038/sj.bjp.0706557. PMC 1751303. PMID 16331283.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi: 10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kuan YH, Gruebl T, Soba P, et al. (2007). "PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2". J. Biol. Chem. 281 (52): 40114–23. doi: 10.1074/jbc.M605407200. PMID 17050537.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123643 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020261 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11959859-5] Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem. 277 (25): 22966–73. doi: 10.1074/jbc.M200374200. PMID 11959859.

[pmid11390972-6] Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A. 98 (13): 7206–11. Bibcode: 2001PNAS...98.7206S. doi: 10.1073/pnas.121183498. PMC 34647. PMID 11390972.

[entrez-7] "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1".

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