From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
Natural cytotoxicity triggering receptor 1 is a
protein that in humans is encoded by the NCR1
gene .
[5]
[6] NCR1 has also been designated as CD335 (
cluster of differentiation , NKP46, NKp46, NK-p46, and LY94 .
[7]
References
^
a
b
c
ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 GRCh38: Ensembl release 89: ENSG00000273535, ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000062524 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998).
"Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity" . J Exp Med . 188 (5): 953–60.
doi :
10.1084/jem.188.5.953 .
PMC
3207313 .
PMID
9730896 .
^
"Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1" .
^
"NCR1 natural cytotoxicity triggering receptor 1 [Homo sapiens (human)] - Gene - NCBI" .
Further reading
Biassoni R, Cantoni C, Marras D, et al. (2004).
"Human natural killer cell receptors: insights into their molecular function and structure" . J. Cell. Mol. Med . 7 (4): 376–87.
doi :
10.1111/j.1582-4934.2003.tb00240.x .
PMC
6740120 .
PMID
14754506 .
Sivori S, Vitale M, Morelli L, et al. (1997).
"p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation" . J. Exp. Med . 186 (7): 1129–36.
doi :
10.1084/jem.186.7.1129 .
PMC
2211712 .
PMID
9314561 .
Vitale M, Bottino C, Sivori S, et al. (1998).
"NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis" . J. Exp. Med . 187 (12): 2065–72.
doi :
10.1084/jem.187.12.2065 .
PMC
2212362 .
PMID
9625766 .
Cantoni C, Bottino C, Vitale M, et al. (1999).
"NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily" . J. Exp. Med . 189 (5): 787–96.
doi :
10.1084/jem.189.5.787 .
PMC
2192947 .
PMID
10049942 .
Vankayalapati R, Wizel B, Weis SE, et al. (2002).
"The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium" . J. Immunol . 168 (7): 3451–7.
doi :
10.4049/jimmunol.168.7.3451 .
PMID
11907104 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Augugliaro R, Parolini S, Castriconi R, et al. (2003).
"Selective cross-talk among natural cytotoxicity receptors in human natural killer cells" . Eur. J. Immunol . 33 (5): 1235–41.
doi :
10.1002/eji.200323896 .
PMID
12731048 .
S2CID
10724743 .
Ponassi M, Cantoni C, Biassoni R, et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun . 309 (2): 317–23.
doi :
10.1016/j.bbrc.2003.08.007 .
PMID
12951052 .
Foster CE, Colonna M, Sun PD (2003).
"Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors" . J. Biol. Chem . 278 (46): 46081–6.
doi :
10.1074/jbc.M308491200 .
PMID
12960161 .
Arnon TI, Achdout H, Lieberman N, et al. (2004).
"The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46" . Blood . 103 (2): 664–72.
doi :
10.1182/blood-2003-05-1716 .
PMID
14504081 .
Marcenaro E, Augugliaro R, Falco M, et al. (2004).
"CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity" . Eur. J. Immunol . 33 (12): 3367–76.
doi :
10.1002/eji.200324425 .
PMID
14635045 .
S2CID
40345630 .
Carbone E, Neri P, Mesuraca M, et al. (2005).
"HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells" . Blood . 105 (1): 251–8.
doi :
10.1182/blood-2004-04-1422 .
PMID
15328155 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Mavoungou E, Bouyou-Akotet MK, Kremsner PG (2005).
"Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)" . Clin. Exp. Immunol . 139 (2): 287–96.
doi :
10.1111/j.1365-2249.2004.02686.x .
PMC
1809301 .
PMID
15654827 .
Nowbakht P, Ionescu MC, Rohner A, et al. (2005).
"Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias" . Blood . 105 (9): 3615–22.
doi :
10.1182/blood-2004-07-2585 .
PMID
15657183 .
Poggi A, Massaro AM, Negrini S, et al. (2005).
"Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors" . J. Immunol . 174 (5): 2653–60.
doi :
10.4049/jimmunol.174.5.2653 .
PMID
15728472 .
Zilka A, Landau G, Hershkovitz O, et al. (2006). "Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46". Biochemistry . 44 (44): 14477–85.
doi :
10.1021/bi051241s .
PMID
16262248 .
Hermann E, Alonso-Vega C, Berthe A, et al. (2006).
"Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells" . Pediatr. Res . 60 (1): 38–43.
doi :
10.1203/01.pdr.0000220335.05588.ea .
PMID
16690951 .
External links
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