| mir-7 microRNA precursor | |
|---|---|
 Predicted
secondary structure and
sequence conservation of mir-7 | |
| Identifiers | |
| Symbol | mir-7 |
| Rfam | RF00053 |
| miRBase | MI0000263 |
| miRBase family | MIPF0000022 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
This family represents the microRNA (miRNA) precursor mir-7. This miRNA has been predicted or experimentally confirmed in a wide range of species. [1] miRNAs are transcribed as ~70 nucleotide precursors (modelled here) and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference.
Mature miRNA-7 is derived from three microRNA precursors in the human genome, miR-7-1, miR-7-2 and miR-7-3. miRNAs are numbered based on the sequence of the mature RNA.
miR-7 is directly regulated by the transcription factor HoxD10. [2]
miRNAs are thought to have regulatory roles through complementarity to mRNA. miR-7 is essential for the maintenance of regulatory stability under conditions of environmental flux. [3] It plays an important role in controlling mRNA expression. The miR-7 gene is found in most sequenced Urbilateria species, and the sequence of its mature miRNA product is perfectly conserved from annelids to humans, indicating a strong functional conservation. [3]
Targets of miR-7
Bioinformatic predictions suggest that the human EGFR mRNA 3'-untranslated region contains three microRNA-7 (miR-7) target sites, which are not conserved across mammals. [4] In Drosophila photoreceptor cells, miR-7 controls epidermal growth factor receptor (EGFR) signaling and promotes photoreceptor differentiation. [5] Among other targets of miR-7 are insulin-like growth factor 1 receptor (IGF1R) and PIK3CD, [6] E(spl) gene family [7] and Pak1 (cancer cells). [2] c-Fos is also a target of miR-7b in mice. [8] Pax6 translation in the lateral wall of the subventricular zone of developed mice is post-transcriptionally regulated by miRNA-7a mediated gene silencing, which is necessary to control the rate of dopaminergic neuron production in the olfactory bulb. [9]
Clinical relevance
Multiple roles and targets of miR-7 as well as its expression pattern were linked to regulatory mechanisms and pathogenesis in glioblastoma, [10] breast cancer [11] and other types of cancers, [4] [6] [12] as well as in schizophrenia [13] and visual abnormalities. [14] Inhibition of the motility, invasiveness, anchorage-independent growth, and tumorigenic potential of highly invasive breast cancer cells through the introduction of miR-7 suggests a strong therapeutic potential of miR-7. [2] [15]
References
- ^ "miRNA gene family: mir-7 (92 sequences)". MiRBase. Archived from the original on 2007-09-29.
- ^ a b c Reddy SD, Ohshiro K, Rayala SK, Kumar R (October 2008). "MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions". Cancer Research. 68 (20): 8195–200. doi: 10.1158/0008-5472.CAN-08-2103. PMC 3636563. PMID 18922890.
- ^ a b Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW (April 2009). "A microRNA imparts robustness against environmental fluctuation during development". Cell. 137 (2): 273–82. doi: 10.1016/j.cell.2009.01.058. PMC 2674871. PMID 19379693.
- ^ a b Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS, Leedman PJ (February 2009). "Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7". The Journal of Biological Chemistry. 284 (9): 5731–41. doi: 10.1074/jbc.M804280200. PMID 19073608.
- ^ Li X, Carthew RW (December 2005). "A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye". Cell. 123 (7): 1267–77. doi: 10.1016/j.cell.2005.10.040. PMID 16377567.
- ^ a b Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X (November 2010). "MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells". The Biochemical Journal. 432 (1): 199–205. doi: 10.1042/BJ20100859. PMC 3130335. PMID 20819078.
-
^ Stark A, Brennecke J, Russell RB, Cohen SM (December 2003).
"Identification of Drosophila MicroRNA targets". PLOS Biology. 1 (3): E60.
doi:
10.1371/journal.pbio.0000060.
PMC
270017.
PMID
14691535.
- ^ Lee HJ, Palkovits M, Young WS (October 2006). "miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation". Proceedings of the National Academy of Sciences of the United States of America. 103 (42): 15669–74. doi: 10.1073/pnas.0605781103. PMC 1622879. PMID 17028171.
- ^ de Chevigny A (2012). "miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons". Nature Neuroscience. 15 (8): 1120–1126. doi: 10.1038/nn.3142. PMID 22729175. S2CID 8456253.
- ^ Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B (May 2008). "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma". Cancer Research. 68 (10): 3566–72. doi: 10.1158/0008-5472.CAN-07-6639. PMID 18483236.
- ^ Foekens JA, Sieuwerts AM, Smid M, Look MP, de Weerd V, Boersma AW, Klijn JG, Wiemer EA, Martens JW (September 2008). "Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer". Proceedings of the National Academy of Sciences of the United States of America. 105 (35): 13021–6. Bibcode: 2008PNAS..10513021F. doi: 10.1073/pnas.0803304105. PMC 2529088. PMID 18755890.
- ^ Veerla S, Lindgren D, Kvist A, Frigyesi A, Staaf J, Persson H, Liedberg F, Chebil G, Gudjonsson S, Borg A, Månsson W, Rovira C, Höglund M (May 2009). "MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31". International Journal of Cancer. 124 (9): 2236–42. doi: 10.1002/ijc.24183. PMID 19127597.
- ^ Perkins DO, Jeffries CD, Jarskog LF, Thomson JM, Woods K, Newman MA, Parker JS, Jin J, Hammond SM (2007). "microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder". Genome Biology. 8 (2): R27. doi: 10.1186/gb-2007-8-2-r27. PMC 1852419. PMID 17326821.
- ^ Arora A, McKay GJ, Simpson DA (September 2007). "Prediction and verification of miRNA expression in human and rat retinas". Investigative Ophthalmology & Visual Science. 48 (9): 3962–7. doi: 10.1167/iovs.06-1221. PMID 17724173.
- ^ Czech MP (March 2006). "MicroRNAs as therapeutic targets". The New England Journal of Medicine. 354 (11): 1194–5. doi: 10.1056/NEJMcibr060065. PMID 16540623.
Further reading
- Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (October 2001). "Identification of novel genes coding for small expressed RNAs". Science. 294 (5543): 853–8. Bibcode: 2001Sci...294..853L. doi: 10.1126/science.1064921. hdl: 11858/00-001M-0000-0012-F65F-2. PMID 11679670. S2CID 18101169.
- Ambros V (December 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi: 10.1016/S0092-8674(01)00616-X. PMID 11779458.
- Chen H, Shalom-Feuerstein R, Riley J, Zhang SD, Tucci P, Agostini M, Aberdam D, Knight RA, Genchi G, Nicotera P, Melino G, Vasa-Nicotera M (April 2010). "miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro". Biochemical and Biophysical Research Communications. 394 (4): 921–7. doi: 10.1016/j.bbrc.2010.03.076. PMID 20230785.
- Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry. 285 (17): 12726–34. doi: 10.1074/jbc.M109.086827. PMC 2857101. PMID 20106983.
- Pek JW, Lim AK, Kai T (September 2009). "Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7". Developmental Cell. 17 (3): 417–24. doi: 10.1016/j.devcel.2009.07.017. PMID 19758565.
- Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM (August 2009). "Repression of alpha-synuclein expression and toxicity by microRNA-7". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 13052–7. Bibcode: 2009PNAS..10613052J. doi: 10.1073/pnas.0906277106. PMC 2722353. PMID 19628698.
- Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL (April 2009). "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expression Patterns. 9 (4): 193–9. doi: 10.1016/j.gep.2008.12.003. PMID 19135553.
External links
- Page for mir-7 microRNA precursor at Rfam
- Purow, Benjamin (December 2008). "MIR7-1 (microRNA 7-1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| mir-7 microRNA precursor | |
|---|---|
|
Predicted
secondary structure and
sequence conservation of mir-7 | |
| Identifiers | |
| Symbol | mir-7 |
| Rfam | RF00053 |
| miRBase | MI0000263 |
| miRBase family | MIPF0000022 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
This family represents the microRNA (miRNA) precursor mir-7. This miRNA has been predicted or experimentally confirmed in a wide range of species. [1] miRNAs are transcribed as ~70 nucleotide precursors (modelled here) and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference.
Mature miRNA-7 is derived from three microRNA precursors in the human genome, miR-7-1, miR-7-2 and miR-7-3. miRNAs are numbered based on the sequence of the mature RNA.
miR-7 is directly regulated by the transcription factor HoxD10. [2]
miRNAs are thought to have regulatory roles through complementarity to mRNA. miR-7 is essential for the maintenance of regulatory stability under conditions of environmental flux. [3] It plays an important role in controlling mRNA expression. The miR-7 gene is found in most sequenced Urbilateria species, and the sequence of its mature miRNA product is perfectly conserved from annelids to humans, indicating a strong functional conservation. [3]
Targets of miR-7
Bioinformatic predictions suggest that the human EGFR mRNA 3'-untranslated region contains three microRNA-7 (miR-7) target sites, which are not conserved across mammals. [4] In Drosophila photoreceptor cells, miR-7 controls epidermal growth factor receptor (EGFR) signaling and promotes photoreceptor differentiation. [5] Among other targets of miR-7 are insulin-like growth factor 1 receptor (IGF1R) and PIK3CD, [6] E(spl) gene family [7] and Pak1 (cancer cells). [2] c-Fos is also a target of miR-7b in mice. [8] Pax6 translation in the lateral wall of the subventricular zone of developed mice is post-transcriptionally regulated by miRNA-7a mediated gene silencing, which is necessary to control the rate of dopaminergic neuron production in the olfactory bulb. [9]
Clinical relevance
Multiple roles and targets of miR-7 as well as its expression pattern were linked to regulatory mechanisms and pathogenesis in glioblastoma, [10] breast cancer [11] and other types of cancers, [4] [6] [12] as well as in schizophrenia [13] and visual abnormalities. [14] Inhibition of the motility, invasiveness, anchorage-independent growth, and tumorigenic potential of highly invasive breast cancer cells through the introduction of miR-7 suggests a strong therapeutic potential of miR-7. [2] [15]
References
- ^ "miRNA gene family: mir-7 (92 sequences)". MiRBase. Archived from the original on 2007-09-29.
- ^ a b c Reddy SD, Ohshiro K, Rayala SK, Kumar R (October 2008). "MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions". Cancer Research. 68 (20): 8195–200. doi: 10.1158/0008-5472.CAN-08-2103. PMC 3636563. PMID 18922890.
- ^ a b Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW (April 2009). "A microRNA imparts robustness against environmental fluctuation during development". Cell. 137 (2): 273–82. doi: 10.1016/j.cell.2009.01.058. PMC 2674871. PMID 19379693.
- ^ a b Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS, Leedman PJ (February 2009). "Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7". The Journal of Biological Chemistry. 284 (9): 5731–41. doi: 10.1074/jbc.M804280200. PMID 19073608.
- ^ Li X, Carthew RW (December 2005). "A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye". Cell. 123 (7): 1267–77. doi: 10.1016/j.cell.2005.10.040. PMID 16377567.
- ^ a b Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X (November 2010). "MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells". The Biochemical Journal. 432 (1): 199–205. doi: 10.1042/BJ20100859. PMC 3130335. PMID 20819078.
-
^ Stark A, Brennecke J, Russell RB, Cohen SM (December 2003).
"Identification of Drosophila MicroRNA targets". PLOS Biology. 1 (3): E60.
doi:
10.1371/journal.pbio.0000060.
PMC
270017.
PMID
14691535.
- ^ Lee HJ, Palkovits M, Young WS (October 2006). "miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation". Proceedings of the National Academy of Sciences of the United States of America. 103 (42): 15669–74. doi: 10.1073/pnas.0605781103. PMC 1622879. PMID 17028171.
- ^ de Chevigny A (2012). "miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons". Nature Neuroscience. 15 (8): 1120–1126. doi: 10.1038/nn.3142. PMID 22729175. S2CID 8456253.
- ^ Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B (May 2008). "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma". Cancer Research. 68 (10): 3566–72. doi: 10.1158/0008-5472.CAN-07-6639. PMID 18483236.
- ^ Foekens JA, Sieuwerts AM, Smid M, Look MP, de Weerd V, Boersma AW, Klijn JG, Wiemer EA, Martens JW (September 2008). "Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer". Proceedings of the National Academy of Sciences of the United States of America. 105 (35): 13021–6. Bibcode: 2008PNAS..10513021F. doi: 10.1073/pnas.0803304105. PMC 2529088. PMID 18755890.
- ^ Veerla S, Lindgren D, Kvist A, Frigyesi A, Staaf J, Persson H, Liedberg F, Chebil G, Gudjonsson S, Borg A, Månsson W, Rovira C, Höglund M (May 2009). "MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31". International Journal of Cancer. 124 (9): 2236–42. doi: 10.1002/ijc.24183. PMID 19127597.
- ^ Perkins DO, Jeffries CD, Jarskog LF, Thomson JM, Woods K, Newman MA, Parker JS, Jin J, Hammond SM (2007). "microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder". Genome Biology. 8 (2): R27. doi: 10.1186/gb-2007-8-2-r27. PMC 1852419. PMID 17326821.
- ^ Arora A, McKay GJ, Simpson DA (September 2007). "Prediction and verification of miRNA expression in human and rat retinas". Investigative Ophthalmology & Visual Science. 48 (9): 3962–7. doi: 10.1167/iovs.06-1221. PMID 17724173.
- ^ Czech MP (March 2006). "MicroRNAs as therapeutic targets". The New England Journal of Medicine. 354 (11): 1194–5. doi: 10.1056/NEJMcibr060065. PMID 16540623.
Further reading
- Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (October 2001). "Identification of novel genes coding for small expressed RNAs". Science. 294 (5543): 853–8. Bibcode: 2001Sci...294..853L. doi: 10.1126/science.1064921. hdl: 11858/00-001M-0000-0012-F65F-2. PMID 11679670. S2CID 18101169.
- Ambros V (December 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi: 10.1016/S0092-8674(01)00616-X. PMID 11779458.
- Chen H, Shalom-Feuerstein R, Riley J, Zhang SD, Tucci P, Agostini M, Aberdam D, Knight RA, Genchi G, Nicotera P, Melino G, Vasa-Nicotera M (April 2010). "miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro". Biochemical and Biophysical Research Communications. 394 (4): 921–7. doi: 10.1016/j.bbrc.2010.03.076. PMID 20230785.
- Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry. 285 (17): 12726–34. doi: 10.1074/jbc.M109.086827. PMC 2857101. PMID 20106983.
- Pek JW, Lim AK, Kai T (September 2009). "Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7". Developmental Cell. 17 (3): 417–24. doi: 10.1016/j.devcel.2009.07.017. PMID 19758565.
- Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM (August 2009). "Repression of alpha-synuclein expression and toxicity by microRNA-7". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 13052–7. Bibcode: 2009PNAS..10613052J. doi: 10.1073/pnas.0906277106. PMC 2722353. PMID 19628698.
- Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL (April 2009). "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expression Patterns. 9 (4): 193–9. doi: 10.1016/j.gep.2008.12.003. PMID 19135553.
External links
- Page for mir-7 microRNA precursor at Rfam
- Purow, Benjamin (December 2008). "MIR7-1 (microRNA 7-1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology.