MicroRNA 141 is a
non-coding RNA molecule that in humans is encoded by the MIR141
gene.
[3]
Function
microRNAs (miRNAs) are short (20-24 nt)
non-coding RNAs that are involved in
post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of
mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
Drosha ribonuclease III enzyme to produce an approximately 70-nt
stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic
Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced
silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T, Si J (2009). "Down-regulation of miR-141 in gastric cancer and its involvement in cell growth". J. Gastroenterol. 44 (6): 556–61.
doi:
10.1007/s00535-009-0037-7.
PMID19363643.
S2CID22265968.
Hu M, Xia M, Chen X, Lin Z, Xu Y, Ma Y, Su L (August 2010). "MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells". Dig. Dis. Sci. 55 (8): 2365–72.
doi:
10.1007/s10620-009-1008-9.
PMID19830559.
S2CID25368290.
MicroRNA 141 is a
non-coding RNA molecule that in humans is encoded by the MIR141
gene.
[3]
Function
microRNAs (miRNAs) are short (20-24 nt)
non-coding RNAs that are involved in
post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of
mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
Drosha ribonuclease III enzyme to produce an approximately 70-nt
stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic
Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced
silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T, Si J (2009). "Down-regulation of miR-141 in gastric cancer and its involvement in cell growth". J. Gastroenterol. 44 (6): 556–61.
doi:
10.1007/s00535-009-0037-7.
PMID19363643.
S2CID22265968.
Hu M, Xia M, Chen X, Lin Z, Xu Y, Ma Y, Su L (August 2010). "MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells". Dig. Dis. Sci. 55 (8): 2365–72.
doi:
10.1007/s10620-009-1008-9.
PMID19830559.
S2CID25368290.