miR-144 | |
---|---|
![]() Conserved
secondary structure of miR-144 precursor microRNA | |
Identifiers | |
Symbol | miR-144 |
Alt. Symbols | MIR144 |
Rfam | RF00682 |
miRBase | MI0000460 |
miRBase family | MIPF0000093 |
NCBI Gene | 406936 |
HGNC | 31531 |
OMIM | 612070 |
RefSeq | NR_029685 |
Other data | |
RNA type | miRNA |
Domain(s) | Mammalia |
GO | 0035195 |
SO | 0001244 |
Locus | Chr. 17 q11.2 |
PDB structures | PDBe |
miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. [1] In humans, miR-144 has been characterised as a "common miRNA signature" [2] of a number of different tumours.
GATA4 is thought to activate transcription of the miR-144 microRNA precursor. [3]
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis. [4] One of the identified targets of miR-144 is insulin receptor substrate 1. [5]
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder. [6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease. [3]
miR-144 | |
---|---|
![]() Conserved
secondary structure of miR-144 precursor microRNA | |
Identifiers | |
Symbol | miR-144 |
Alt. Symbols | MIR144 |
Rfam | RF00682 |
miRBase | MI0000460 |
miRBase family | MIPF0000093 |
NCBI Gene | 406936 |
HGNC | 31531 |
OMIM | 612070 |
RefSeq | NR_029685 |
Other data | |
RNA type | miRNA |
Domain(s) | Mammalia |
GO | 0035195 |
SO | 0001244 |
Locus | Chr. 17 q11.2 |
PDB structures | PDBe |
miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. [1] In humans, miR-144 has been characterised as a "common miRNA signature" [2] of a number of different tumours.
GATA4 is thought to activate transcription of the miR-144 microRNA precursor. [3]
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis. [4] One of the identified targets of miR-144 is insulin receptor substrate 1. [5]
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder. [6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease. [3]