In molecular biology, mir-145 microRNA is a short
RNA molecule that in humans is encoded by the MIR145
gene.
MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[3]
Targets
MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule
JAM-A as well as the actin bundling protein fascin in
breast cancer and
endometriosis cells, resulting in a reduction of
cell motility.[4][5] Larsson et al.[6] showed that miR-145 targets the 3' UTR of the
FLI1 gene, a finding that was later supported by Zhang et al.[7]
^
abGötte M, Mohr C, Koo CY, et al. (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80.
doi:
10.1038/onc.2010.386.
PMID20818426.
S2CID11455884.
^Slaby O, Svoboda M, Fabian P, et al. (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology. 72 (5–6): 397–402.
doi:
10.1159/000113489.
PMID18196926.
S2CID207615720.
Ostenfeld MS, Bramsen JB, Lamy P, et al. (Feb 2010). "miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors". Oncogene. 29 (7): 1073–84.
doi:
10.1038/onc.2009.395.
PMID19915607.
S2CID25309570.
Starczynowski DT, Kuchenbauer F, Argiropoulos B, et al. (Jan 2010). "Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype". Nature Medicine. 16 (1): 49–58.
doi:
10.1038/nm.2054.
PMID19898489.
S2CID7987486.
Cho WC, Chow AS, Au JS (Aug 2009). "Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation". European Journal of Cancer. 45 (12): 2197–206.
doi:
10.1016/j.ejca.2009.04.039.
PMID19493678.
La Rocca G, Badin M, Shi B, et al. (Aug 2009). "Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway". Journal of Cellular Physiology. 220 (2): 485–91.
doi:
10.1002/jcp.21796.
PMID19391107.
S2CID44343336.
In molecular biology, mir-145 microRNA is a short
RNA molecule that in humans is encoded by the MIR145
gene.
MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[3]
Targets
MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule
JAM-A as well as the actin bundling protein fascin in
breast cancer and
endometriosis cells, resulting in a reduction of
cell motility.[4][5] Larsson et al.[6] showed that miR-145 targets the 3' UTR of the
FLI1 gene, a finding that was later supported by Zhang et al.[7]
^
abGötte M, Mohr C, Koo CY, et al. (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80.
doi:
10.1038/onc.2010.386.
PMID20818426.
S2CID11455884.
^Slaby O, Svoboda M, Fabian P, et al. (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology. 72 (5–6): 397–402.
doi:
10.1159/000113489.
PMID18196926.
S2CID207615720.
Ostenfeld MS, Bramsen JB, Lamy P, et al. (Feb 2010). "miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors". Oncogene. 29 (7): 1073–84.
doi:
10.1038/onc.2009.395.
PMID19915607.
S2CID25309570.
Starczynowski DT, Kuchenbauer F, Argiropoulos B, et al. (Jan 2010). "Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype". Nature Medicine. 16 (1): 49–58.
doi:
10.1038/nm.2054.
PMID19898489.
S2CID7987486.
Cho WC, Chow AS, Au JS (Aug 2009). "Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation". European Journal of Cancer. 45 (12): 2197–206.
doi:
10.1016/j.ejca.2009.04.039.
PMID19493678.
La Rocca G, Badin M, Shi B, et al. (Aug 2009). "Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway". Journal of Cellular Physiology. 220 (2): 485–91.
doi:
10.1002/jcp.21796.
PMID19391107.
S2CID44343336.