miR-338 | |
---|---|
Identifiers | |
Symbol | miR-338 |
Alt. Symbols | MIR338 |
Rfam | RF00686 |
miRBase | MI0000814 |
miRBase family | MIPF0000097 |
NCBI Gene | 442906 |
HGNC | 31775 |
OMIM | 614059 |
RefSeq | NR_029897 |
Other data | |
RNA type | miRNA |
Domain(s) | Mammalia |
GO | 0035195 |
SO | 0001244 |
Locus | Chr. 17 q25.3 |
PDB structures | PDBe |
miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. [1] The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. [2] This sequence then associates with RISC which effects RNA interference. [3]
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase ( AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression. [4]
miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4). [1] [5] The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing. [5]
miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent. [6] miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples. [7] Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer. [8]
{{
cite journal}}
: CS1 maint: DOI inactive as of April 2024 (
link) (Chinese)
miR-338 | |
---|---|
Identifiers | |
Symbol | miR-338 |
Alt. Symbols | MIR338 |
Rfam | RF00686 |
miRBase | MI0000814 |
miRBase family | MIPF0000097 |
NCBI Gene | 442906 |
HGNC | 31775 |
OMIM | 614059 |
RefSeq | NR_029897 |
Other data | |
RNA type | miRNA |
Domain(s) | Mammalia |
GO | 0035195 |
SO | 0001244 |
Locus | Chr. 17 q25.3 |
PDB structures | PDBe |
miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. [1] The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. [2] This sequence then associates with RISC which effects RNA interference. [3]
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase ( AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression. [4]
miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4). [1] [5] The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing. [5]
miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent. [6] miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples. [7] Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer. [8]
{{
cite journal}}
: CS1 maint: DOI inactive as of April 2024 (
link) (Chinese)