Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a
protein that in humans is encoded by the TXLNAgene.[5][6][7]
Interleukin-14 is a
cytokine that controls the growth and
proliferation of both normal and cancerous B cells.[8] This molecule was also recently designated taxilin.[9] IL-14 induces B-cell proliferation, inhibits
antibody secretion, and expands selected B-cell subgroups. This
interleukin is produced mainly by
T cells and certain
malignant B cells.
Gene
In murine models, two distinct
transcripts are produced from opposite strands of the il14gene that are called IL-14α and IL-14β.[10] The il14 locus is near the gene for
LCK on
chromosome 1 in humans.
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43.
doi:
10.1016/j.bbrc.2004.05.073.
PMID15184072.
^Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802.
doi:
10.1016/j.bbrc.2003.10.069.
PMID14623251.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a
protein that in humans is encoded by the TXLNAgene.[5][6][7]
Interleukin-14 is a
cytokine that controls the growth and
proliferation of both normal and cancerous B cells.[8] This molecule was also recently designated taxilin.[9] IL-14 induces B-cell proliferation, inhibits
antibody secretion, and expands selected B-cell subgroups. This
interleukin is produced mainly by
T cells and certain
malignant B cells.
Gene
In murine models, two distinct
transcripts are produced from opposite strands of the il14gene that are called IL-14α and IL-14β.[10] The il14 locus is near the gene for
LCK on
chromosome 1 in humans.
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43.
doi:
10.1016/j.bbrc.2004.05.073.
PMID15184072.
^Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802.
doi:
10.1016/j.bbrc.2003.10.069.
PMID14623251.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.