Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an
enzyme that in humans is encoded by the GUCY2Cgene.[5][6]
GC-C is a key
receptor for heat-stable
enterotoxins that are responsible for
acute secretory diarrhea.[8] Heat-stable enterotoxins are produced by
pathogens such as Escherichia coli.
Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with
cholera toxin. This demonstrates the specificity of the GC-C receptor.
Park J, Schulz S, Haaf J, et al. (2002). "Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach". Cancer Epidemiol. Biomarkers Prev. 11 (8): 739–44.
PMID12163327.
Tien YW, Lee PH, Hu RH, et al. (2003). "The role of gelatinase in hepatic metastasis of colorectal cancer". Clin. Cancer Res. 9 (13): 4891–6.
PMID14581363.
Bhandari R, Srinivasan N, Mahaboobi M, et al. (2001). "Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain". Biochemistry. 40 (31): 9196–206.
doi:
10.1021/bi002595g.
PMID11478887.
Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an
enzyme that in humans is encoded by the GUCY2Cgene.[5][6]
GC-C is a key
receptor for heat-stable
enterotoxins that are responsible for
acute secretory diarrhea.[8] Heat-stable enterotoxins are produced by
pathogens such as Escherichia coli.
Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with
cholera toxin. This demonstrates the specificity of the GC-C receptor.
Park J, Schulz S, Haaf J, et al. (2002). "Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach". Cancer Epidemiol. Biomarkers Prev. 11 (8): 739–44.
PMID12163327.
Tien YW, Lee PH, Hu RH, et al. (2003). "The role of gelatinase in hepatic metastasis of colorectal cancer". Clin. Cancer Res. 9 (13): 4891–6.
PMID14581363.
Bhandari R, Srinivasan N, Mahaboobi M, et al. (2001). "Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain". Biochemistry. 40 (31): 9196–206.
doi:
10.1021/bi002595g.
PMID11478887.