(Redirected from
B lymphocyte kinase)
Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. [5] [6] It is of the Src family of tyrosine kinases.
Interactions
The tyrosine-protein kinase BLK has been shown to interact with UBE3A. [7]
References
- ^ a b c ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014453 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
- ^ "Entrez Gene: BLK B lymphoid tyrosine kinase".
- ^ Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode: 1999PNAS...96.9557O. doi: 10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
Further reading
- Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells". Science. 247 (4940): 332–6. Bibcode: 1990Sci...247..332D. doi: 10.1126/science.2404338. PMID 2404338.
- Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters". J. Biol. Chem. 270 (43): 25968–75. doi: 10.1074/jbc.270.43.25968. PMID 7592787.
- Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi: 10.1074/jbc.270.45.27072. PMID 7592958.
- Islam KB, Rabbani H, Larsson C, et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk". J. Immunol. 154 (3): 1265–72. doi: 10.4049/jimmunol.154.3.1265. PMID 7822795. S2CID 10329710.
- Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". J. Biol. Chem. 269 (37): 22921–4. doi: 10.1016/S0021-9258(17)31595-8. PMID 8083187.
- Pleiman CM, Clark MR, Gauen LK, et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. doi: 10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016.
- Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J. Biol. Chem. 271 (12): 6952–62. doi: 10.1074/jbc.271.12.6952. PMID 8636124.
- Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. doi: 10.1128/MCB.16.9.4735. PMC 231474. PMID 8756631.
- Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi: 10.1006/bbrc.1997.6638. PMID 9177269.
- Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6. doi: 10.1074/jbc.273.14.7783. PMID 9525867.
- Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode: 1999PNAS...96.9557O. doi: 10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
- Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi: 10.1038/sj.ejhg.5200750. PMID 11896452.
- Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. doi: 10.1016/S0304-3835(02)00055-1. PMID 12406557.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi: 10.1074/jbc.M309074200. PMID 14970218.
 | This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it. |
(Redirected from
B lymphocyte kinase)
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| Aliases | BLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 191305 MGI: 88169 HomoloGene: 1297 GeneCards: BLK | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. [5] [6] It is of the Src family of tyrosine kinases.
Interactions
The tyrosine-protein kinase BLK has been shown to interact with UBE3A. [7]
References
- ^ a b c ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014453 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
- ^ "Entrez Gene: BLK B lymphoid tyrosine kinase".
- ^ Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode: 1999PNAS...96.9557O. doi: 10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
Further reading
- Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells". Science. 247 (4940): 332–6. Bibcode: 1990Sci...247..332D. doi: 10.1126/science.2404338. PMID 2404338.
- Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters". J. Biol. Chem. 270 (43): 25968–75. doi: 10.1074/jbc.270.43.25968. PMID 7592787.
- Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi: 10.1074/jbc.270.45.27072. PMID 7592958.
- Islam KB, Rabbani H, Larsson C, et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk". J. Immunol. 154 (3): 1265–72. doi: 10.4049/jimmunol.154.3.1265. PMID 7822795. S2CID 10329710.
- Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". J. Biol. Chem. 269 (37): 22921–4. doi: 10.1016/S0021-9258(17)31595-8. PMID 8083187.
- Pleiman CM, Clark MR, Gauen LK, et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. doi: 10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016.
- Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J. Biol. Chem. 271 (12): 6952–62. doi: 10.1074/jbc.271.12.6952. PMID 8636124.
- Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. doi: 10.1128/MCB.16.9.4735. PMC 231474. PMID 8756631.
- Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi: 10.1006/bbrc.1997.6638. PMID 9177269.
- Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6. doi: 10.1074/jbc.273.14.7783. PMID 9525867.
- Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode: 1999PNAS...96.9557O. doi: 10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
- Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi: 10.1038/sj.ejhg.5200750. PMID 11896452.
- Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. doi: 10.1016/S0304-3835(02)00055-1. PMID 12406557.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi: 10.1074/jbc.M309074200. PMID 14970218.
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| This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it. |