^Kosaka Y, Felices M, Berg LJ (October 2006). "Itk and Th2 responses: action but no reaction". Trends Immunol. 27 (10): 453–60.
doi:
10.1016/j.it.2006.08.006.
PMID16931156.{{
cite journal}}: CS1 maint: date and year (
link) CS1 maint: multiple names: authors list (
link)
^Hawkins J, Marcy A (July 2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity". Protein Expr. Purif. 22 (2): 211–9.
doi:
10.1006/prep.2001.1447.
PMID11437596.{{
cite journal}}: CS1 maint: date and year (
link)
Janis EM, Siliciano JD, Isaac DD; et al. (1995). "Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q". Genomics. 23 (1): 269–71.
doi:
10.1006/geno.1994.1492.
PMID7829087. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Gibson S, Leung B, Squire JA; et al. (1993). "Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q". Blood. 82 (5): 1561–72.
doi:
10.1182/blood.V82.5.1561.1561.
PMID8364206. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Tanaka N, Asao H, Ohtani K; et al. (1993). "A novel human tyrosine kinase gene inducible in T cells by interleukin 2". FEBS Lett. 324 (1): 1–5.
doi:
10.1016/0014-5793(93)81520-A.
PMID8504851. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Rawlings DJ, Scharenberg AM, Park H; et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5.
doi:
10.1126/science.271.5250.822.
PMID8629002. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Park H, Wahl MI, Afar DE; et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25.
doi:
10.1016/S1074-7613(00)80417-3.
PMID8630736. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Andreotti AH, Bunnell SC, Feng S; et al. (1997). "Regulatory intramolecular association in a tyrosine kinase of the Tec family". Nature. 385 (6611): 93–7.
doi:
10.1038/385093a0.
PMID8985255. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
King PD, Sadra A, Teng JM; et al. (1997). "Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK". J. Immunol. 158 (2): 580–90.
doi:
10.4049/jimmunol.158.2.580.
PMID8992971. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
De Sepulveda P, Okkenhaug K, Rose JL; et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15.
doi:
10.1093/emboj/18.4.904.
PMID10022833. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Kaukonen J, Savolainen ER, Palotie A (1999). "Human Emt tyrosine kinase is specifically expressed both in mature T-lymphocytes and T-cell associated hematopoietic malignancies". Leuk. Lymphoma. 32 (5–6): 513–22.
doi:
10.3109/10428199909058409.
PMID10048424.{{
cite journal}}: CS1 maint: multiple names: authors list (
link)
Perez-Villar JJ, Kanner SB (2000). "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes". J. Immunol. 163 (12): 6435–41.
doi:
10.4049/jimmunol.163.12.6435.
PMID10586033.
Rajagopal K, Sommers CL, Decker DC; et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657–68.
doi:
10.1084/jem.190.11.1657.
PMID10587356. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Shan X, Czar MJ, Bunnell SC; et al. (2000). "Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation". Mol. Cell. Biol. 20 (18): 6945–57.
doi:
10.1128/MCB.20.18.6945-6957.2000.
PMID10958690. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Hawkins J, Marcy A (2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity". Protein Expr. Purif. 22 (2): 211–9.
doi:
10.1006/prep.2001.1447.
PMID11437596.
PDB gallery
1lui: NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures
1luk: NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure
1lum: NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures
1lun: NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure
1sm2: Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain
1snu: Crystal structure of the unphosphorylated interleukin-2 tyrosine kinase catalytic domain
1snx: Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain
2etz: The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide
2eu0: The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide
^Kosaka Y, Felices M, Berg LJ (October 2006). "Itk and Th2 responses: action but no reaction". Trends Immunol. 27 (10): 453–60.
doi:
10.1016/j.it.2006.08.006.
PMID16931156.{{
cite journal}}: CS1 maint: date and year (
link) CS1 maint: multiple names: authors list (
link)
^Hawkins J, Marcy A (July 2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity". Protein Expr. Purif. 22 (2): 211–9.
doi:
10.1006/prep.2001.1447.
PMID11437596.{{
cite journal}}: CS1 maint: date and year (
link)
Janis EM, Siliciano JD, Isaac DD; et al. (1995). "Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q". Genomics. 23 (1): 269–71.
doi:
10.1006/geno.1994.1492.
PMID7829087. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Gibson S, Leung B, Squire JA; et al. (1993). "Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q". Blood. 82 (5): 1561–72.
doi:
10.1182/blood.V82.5.1561.1561.
PMID8364206. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Tanaka N, Asao H, Ohtani K; et al. (1993). "A novel human tyrosine kinase gene inducible in T cells by interleukin 2". FEBS Lett. 324 (1): 1–5.
doi:
10.1016/0014-5793(93)81520-A.
PMID8504851. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Rawlings DJ, Scharenberg AM, Park H; et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5.
doi:
10.1126/science.271.5250.822.
PMID8629002. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Park H, Wahl MI, Afar DE; et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25.
doi:
10.1016/S1074-7613(00)80417-3.
PMID8630736. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Andreotti AH, Bunnell SC, Feng S; et al. (1997). "Regulatory intramolecular association in a tyrosine kinase of the Tec family". Nature. 385 (6611): 93–7.
doi:
10.1038/385093a0.
PMID8985255. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
King PD, Sadra A, Teng JM; et al. (1997). "Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK". J. Immunol. 158 (2): 580–90.
doi:
10.4049/jimmunol.158.2.580.
PMID8992971. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
De Sepulveda P, Okkenhaug K, Rose JL; et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15.
doi:
10.1093/emboj/18.4.904.
PMID10022833. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Kaukonen J, Savolainen ER, Palotie A (1999). "Human Emt tyrosine kinase is specifically expressed both in mature T-lymphocytes and T-cell associated hematopoietic malignancies". Leuk. Lymphoma. 32 (5–6): 513–22.
doi:
10.3109/10428199909058409.
PMID10048424.{{
cite journal}}: CS1 maint: multiple names: authors list (
link)
Perez-Villar JJ, Kanner SB (2000). "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes". J. Immunol. 163 (12): 6435–41.
doi:
10.4049/jimmunol.163.12.6435.
PMID10586033.
Rajagopal K, Sommers CL, Decker DC; et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657–68.
doi:
10.1084/jem.190.11.1657.
PMID10587356. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Shan X, Czar MJ, Bunnell SC; et al. (2000). "Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation". Mol. Cell. Biol. 20 (18): 6945–57.
doi:
10.1128/MCB.20.18.6945-6957.2000.
PMID10958690. {{
cite journal}}: Explicit use of et al. in: |author= (
help)CS1 maint: multiple names: authors list (
link)
Hawkins J, Marcy A (2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity". Protein Expr. Purif. 22 (2): 211–9.
doi:
10.1006/prep.2001.1447.
PMID11437596.
PDB gallery
1lui: NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures
1luk: NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure
1lum: NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures
1lun: NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure
1sm2: Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain
1snu: Crystal structure of the unphosphorylated interleukin-2 tyrosine kinase catalytic domain
1snx: Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain
2etz: The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide
2eu0: The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide