This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the
src family. This gene lies in close proximity to
thymidylate synthase gene on
chromosome 18, and a corresponding
pseudogene has been found on chromosome 22.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40.
Bibcode:
1985Sci...227.1038S.
doi:
10.1126/science.2983418.
PMID2983418.
^Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2): 289–96.
doi:
10.1006/bbrc.1996.1023.
ISSN0006-291X.
PMID8702385.
Brickell PM (1992). "The p60c-src family of protein-tyrosine kinases: structure, regulation, and function". Critical Reviews in Oncogenesis. 3 (4): 401–46.
PMID1384720.
Toyoshima K, Semba K, Nishizawa M, et al. (1988). "Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family". Int. Symp. Princess Takamatsu Cancer Res. Fund. 17: 11–20.
PMID3332005.
Krueger J, Zhao YH, Murphy D, Sudol M (1991). "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis". Oncogene. 6 (6): 933–40.
PMID2067846.
Zhao YH, Krueger JG, Sudol M (1991). "Expression of cellular-yes protein in mammalian tissues". Oncogene. 5 (11): 1629–35.
PMID2267131.
Silverman GA, Kuo WL, Taillon-Miller P, Gray JW (1993). "Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18". Genomics. 15 (2): 442–5.
doi:
10.1006/geno.1993.1086.
PMID8449516.
External links
Overview of all the structural information available in the
PDB for
UniProt: P07947 (Tyrosine-protein kinase Yes) at the
PDBe-KB.
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the
src family. This gene lies in close proximity to
thymidylate synthase gene on
chromosome 18, and a corresponding
pseudogene has been found on chromosome 22.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40.
Bibcode:
1985Sci...227.1038S.
doi:
10.1126/science.2983418.
PMID2983418.
^Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2): 289–96.
doi:
10.1006/bbrc.1996.1023.
ISSN0006-291X.
PMID8702385.
Brickell PM (1992). "The p60c-src family of protein-tyrosine kinases: structure, regulation, and function". Critical Reviews in Oncogenesis. 3 (4): 401–46.
PMID1384720.
Toyoshima K, Semba K, Nishizawa M, et al. (1988). "Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family". Int. Symp. Princess Takamatsu Cancer Res. Fund. 17: 11–20.
PMID3332005.
Krueger J, Zhao YH, Murphy D, Sudol M (1991). "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis". Oncogene. 6 (6): 933–40.
PMID2067846.
Zhao YH, Krueger JG, Sudol M (1991). "Expression of cellular-yes protein in mammalian tissues". Oncogene. 5 (11): 1629–35.
PMID2267131.
Silverman GA, Kuo WL, Taillon-Miller P, Gray JW (1993). "Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18". Genomics. 15 (2): 442–5.
doi:
10.1006/geno.1993.1086.
PMID8449516.
External links
Overview of all the structural information available in the
PDB for
UniProt: P07947 (Tyrosine-protein kinase Yes) at the
PDBe-KB.