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Other names | trans-4-hydroxycrotonic acid |
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Formula | C4H6O3 |
Molar mass | 102.089 g·mol−1 |
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trans-4-Hydroxycrotonic acid (T-HCA), also known as γ-hydroxycrotonic acid (GHC), is an agent used in scientific research to study the GHB receptor. [1] It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. [2] [3] [4] Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well. [3] [5] T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, [6] where it acts as an agonist, [1] [7] but does not bind to the low-affinity GHB binding site, the GABAB receptor. [3] [8] Because of this, T-HCA does not produce sedation. T-HCA has been shown to cause receptor activation-evoked increases in extracellular glutamate concentrations, notably in the hippocampus. [8]
![]() | |
Clinical data | |
---|---|
Other names | trans-4-hydroxycrotonic acid |
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C4H6O3 |
Molar mass | 102.089 g·mol−1 |
3D model ( JSmol) | |
| |
| |
![]() ![]() |
trans-4-Hydroxycrotonic acid (T-HCA), also known as γ-hydroxycrotonic acid (GHC), is an agent used in scientific research to study the GHB receptor. [1] It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. [2] [3] [4] Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well. [3] [5] T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, [6] where it acts as an agonist, [1] [7] but does not bind to the low-affinity GHB binding site, the GABAB receptor. [3] [8] Because of this, T-HCA does not produce sedation. T-HCA has been shown to cause receptor activation-evoked increases in extracellular glutamate concentrations, notably in the hippocampus. [8]